Gilbert syndrome

Introduction to Gilbert Syndrome Gilbert syndrome is also known as constitutional liver dysfunction, hereditary non-hemolytic hyperbilirubinemia. It is a congenital non-hemolytic indirect bilirubin-enhancing jaundice. More common in young men, may have a family history. Mainly due to the uptake of bilirubin and bilirubin into the microsomes by hepatocytes, or the lack of glucuronyltransferase activity in hepatocytes, the indirect bilirubin in the blood is increased. The disease is more common in men and can occur in any person, but it is more common in 15-20 years old. The patient has no obvious symptoms and is generally in good condition. basic knowledge The proportion of illness: 0.098% Susceptible people: more common in young men, more common in 15 to 20 years old Mode of transmission: mother-to-child transmission Complications: Neonatal hepatitis Viral hepatitis

Cause of Gilbert syndrome

Mainly due to the uptake of bilirubin and bilirubin into the microsomes by hepatocytes, or the lack of glucuronyltransferase activity in hepatocytes, the indirect bilirubin in the blood is increased.

Gilbert Syndrome Prevention

Various incentives should be avoided. When the jaundice appears, liver enzyme inducer, such as phenobarbital 60 mg, 3 times a day, orally, can be used to increase the activity of glucuronyltransferase in hepatocytes, thereby reducing the indirect bilirubin in the blood.

Gilbert syndrome complications Complications neonatal hepatitis virus hepatitis

Bilirubin encephalopathy, congenital biliary atresia, neonatal hepatitis, viral hepatitis, etc.

Gilbert syndrome symptoms Common symptoms Dyspepsia jaundice hemolytic jaundice weakness

The disease is more common in men, can occur in any person, but more common in 15-20 years old, the patient has no obvious symptoms, the general condition is good, the clinical features of chronic or recurrent jaundice, jaundice can be stable or obvious Fluctuation, emotional excitement, fatigue, cold, drinking, and infection can make the jaundice worse, jaundice is weak, dyspepsia or mild liver pain, pay attention to the identification of hemolytic jaundice.

Gilbert syndrome check

Liver function test ALT normal or mild increase, serum total bilirubin increased, mainly unconjugated bilirubin, low calorie card (400 kcal / d) test, blood non-conjugated bilirubin exceeded the original level after 24 hours 1 More than 5%; luminal test positive, luminal 180mg / d, oral for three days, non-conjugated bilirubin decreased by more than 50%, and even normal, erythrocyte fragility test is normal, reticulocytes are not high.

Imaging examination showed good gallbladder imaging.

Diagnosis and identification of Gilbert syndrome

diagnosis

Diagnosis can be based on medical history, clinical symptoms, and laboratory tests.

Differential diagnosis

Note the identification with hemolytic jaundice, obstructive jaundice, and hepatitis B.

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