Turcot syndrome

Introduction to Turcot Syndrome Familial colon tumors with multiple tumor syndrome were proposed by Turcot in 1959, so it is also called Turcot syndrome. The disease is characterized by a family of colonic polyposis with tumors in other parts of the body. Usually combined with central nervous system tumors, such as neural tube matrix tumors, glioblastoma, also known as glioma polyposis syndrome, clinically rare, is an autosomal recessive hereditary disease. basic knowledge The proportion of illness: 0.002% Susceptible people: no specific population Mode of infection: non-infectious Complications: intestinal obstruction

Cause of Turcot Syndrome

The colon adenoma lesions of this disease are similar to familial polyposis, but most of them are multiple papillary adenomas, which are sparsely distributed in the intestine. Some patients have only a few adenomas in the intestine, but not uniform and dense. At the same time, there are central nervous system tumors, such as glioma, medulloblastoma, etc., in addition to other parts of the tumor, such as thyroid tumor, duodenum, small intestine adenoma, hamartoma, carcinoid, etc. The possibility of malignant transformation of this disease is very high.

Turcot syndrome prevention

It is rare in clinical practice and is an autosomal recessive hereditary disease. It is highly likely that this disease will undergo malignant transformation. Prenatal and postnatal care is the most important preventive measure for this disease.

Turcot syndrome complications Complications, intestinal obstruction

Intestinal obstruction, neural tube matrix tissue tumor, glioblastoma, brain tumor.

Symcot syndrome symptoms common symptoms abdominal discomfort polyps abdominal pain diarrhea thin stool blood dizziness nausea

The clinical manifestations of this disease before malignant transformation are similar to familial polyposis, which may include intermittent abdominal pain, abdominal discomfort, diarrhea, blood in the stool, blood in the stool, weight loss, malnutrition, anemia, intestinal obstruction due to hyperplasia, accompanied by Symptoms of central nervous tumors Symptoms of neurological tumors are often prominent, such as headache, dizziness, nausea and vomiting, visual and physical activity disorders, often dying from brain tumors before malignant transformation.

Examination of Turcot syndrome

Double colonography, fiberoptic colonoscopy, CT, MRI.

Diagnosis and identification of Turcot syndrome

Diagnosis can be based on medical history, clinical manifestations, and laboratory tests.

Differential diagnosis

1. Intestinal primary disease: inflammatory lesions, vascular lesions, structural lesions of the intestinal wall.

2. Systemic diseases involve the intestines: leukemia, bleeding disorders, etc.

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