Intraepidermal neutrophil IgA skin disease

Introduction to neutrophil IgA dermatosis in the epidermis Intraepidermal neutrophilic IgAdermatosis is a chronic bullous skin disease reported by Huff et al in 1985 in adult males with special histopathology and immunological manifestations. basic knowledge The proportion of sickness: 0.00125% Susceptible people: good for adult males Mode of infection: non-infectious Complications: polymorphic erythema

The cause of neutrophil IgA dermatosis in the epidermis

(1) Causes of the disease

The cause is still unclear.

(two) pathogenesis

Histopathology: Neutrophil extravasation at some true epidermal junctions of neutrophils arranged in a line, followed by the formation of micro-abscess in the epidermis, without spine release.

Direct immunofluorescence showed intercellular IgA deposition, and the basal cell layer also had mildly stained, non-circulating autoantibodies.

Prevention of neutrophil IgA skin disease in the epidermis

There is no effective preventive measure for this disease. Early detection and early diagnosis are the key to the prevention and treatment of this disease.

Symptoms of neutrophil IgA dermatosis in the epidermis Complications polymorphic erythema

No special complications.

Symptoms of neutrophil IgA in the epidermis Common symptoms Pustular skin blisters or bullae damage scarring skin blisters, posterior...

It can be divided into two types, one is similar to pemphigus, the other is similar to pustulosis under the cornea. The former is a generalized loose blisters, which quickly breaks down, scars, no scars after the healing, no mucosal damage. Does not affect the limbs, face and neck, the skin lesions are irregularly arranged, the latter is a limp and ring pustule.

According to its characteristic clinical manifestations, histopathological changes and immunopathological intercellular IgA deposition can be basically determined.

Examination of neutrophil IgA skin disease in the epidermis

Histopathology: neutrophil extravasation, at some true epidermal junctions, neutrophils are arranged in a line, followed by the formation of micro-abscess in the epidermis, without spine release.

Direct immunofluorescence showed intercellular IgA deposition, and the basal cell layer was also slightly stained with no circulating autoantibodies.

Diagnosis and differentiation of neutrophil IgA skin disease in the epidermis

According to its characteristic clinical manifestations, histopathological changes and immunopathological intercellular IgA deposition can be basically determined.

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