Spindle cell hemangioendothelioma

Brief introduction of spindle cell vascular endothelial cell tumor Spindle cell vascular endothelial cell tumor (spindlecellhemangioendothelioma) was first reported by Weiss and Enzinger in 1986. This disease is a non-neoplastic, reactive vascular hyperplasia with vascular malformation and periodic recanalization after thrombosis. basic knowledge The proportion of illness: 0.001% Susceptible people: no special people Mode of infection: non-infectious Complications: hemangioendothelioma

The cause of spindle cell vascular endothelial cell tumor

(1) Causes of the disease

The cause is still unknown.

(two) pathogenesis

The pathogenesis is still unclear.

Spindle cell vascular endothelial cell tumor prevention

Eat more fresh fruits and vegetables, drink more water, exercise more, keep your mood comfortable, and have a stable mood. Eat low-fat, low-cholesterol foods. Low-cholesterol foods include mushrooms, fungus, and celery. The oil used daily should use vegetable oil instead of animal oil. Eat less chili, raw garlic and other spicy foods. Cooking, steaming, simmering, frying, mixing, simmering, stewing, cooking methods without frying, frying, roasting, and smoked.

Spindle cell vascular endothelial cell tumor complications Complications

Hemangioendothelioma.

Spindle cell lipomas and pleomorphic lipomas have similar cytogenetic changes. The karyotype is more complex than common lipoma, common subdiploid, often with multiple sites missing, no redundant sequences, and few balanced translocations. It has been reported that 7 to 8 of 10 patients have a single or partial deletion of chromosome 13 or 16. Half of the tumors involving chromosome 16 had a 16q13 breakpoint, and all cases had a 16q13-qter deletion.

Spindle cell vascular endothelial cell tumor symptoms common symptoms microthrombus formation subcutaneous nodules vascular malformation angiogenesis edema

Lesions are single or multiple blue solid nodules in the dermis or subcutaneous tissue. In months or years, the size and number gradually increase, and the diameter can reach several centimeters. When damage occurs frequently, it usually occurs in The same anatomical site, but there are also reports of symmetry occurring in the bilateral hands. Occasionally, multiple lesions occur in different parts. This disease can occur in Maffucci syndrome, occasionally in Klippel-trenaunay syndrome, varicose veins and Milroy congenital lymphedema, common in children and adolescents.

The disease often recurs after local resection, the same patient can recur multiple times, but the disease has not metastasized and thus died.

Examination of spindle cell vascular endothelial cell tumor

Histopathology: The histological features of this disease are:

1. Thin-walled cavernous blood vessels, sometimes filled with organised thrombosis and venous stones.

2. The solid cell area mainly composed of spindle cells, the ratio of sponge-like gap to spindle-shaped cells, the spindle-shaped cells can form a fissure-like gap network, and can form short bundles, and the fusiform cells are often scattered in the small group epithelium. The cytoplasmic cavity is formed in the epithelioid cell area. Occasionally, the vacuolar cells are lining the vascular space, and the cell atypical and mitotic figures are not obvious. Most of the endothelial cell lining cells are positive for the factor 8 antigen. Epithelioid cells were also positive and spindle cells were rarely positive. One case of Beans was also positive for hemagglutinin staining, while spindle cells were negative.

Diagnosis and diagnosis of spindle cell vascular endothelial cell tumor

According to clinical manifestations, combined with histopathological features can be diagnosed.

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