Sebaceous cyst disease

Introduction to sebaceous cyst disease Multiple fatty vesicles (steatocystomamultiplex) are more common, mostly autosomal dominant inheritance. Electron microscopic examination confirmed that the cystic wall is composed of keratinocytes. The cells are connected by desmosomes, and sebaceous gland lobules are visible in the cyst wall. Cystic nodules of different sizes, ranging from a few millimeters to 20 mm or more in diameter, histopathology: the wall of the capsule is wrinkled, composed of several layers of epidermal cells, which can be diagnosed according to clinical manifestations and histopathology. Generally do not need treatment, the wall is not removed, common recurrence. basic knowledge The proportion of illness: 0.02% Susceptible people: no special people Mode of infection: non-infectious Complications: faba bean disease

The cause of sebaceous cyst disease

(1) Causes of the disease

Most are autosomal dominant.

(two) pathogenesis

Electron microscopic examination confirmed that the cyst wall was composed of keratinocytes. The cells were connected by desmosomes, and sebaceous gland lobules were seen in the cyst wall, suggesting that the tumor is a sputum-like or hamartomaous disease at the junction of the hair-sebum gland.

Sebaceous cyst disease prevention

Most of the disease is autosomal dominant hereditary disease, and secondly it may have certain correlation with environmental factors, dietary factors, mood and nutrition during pregnancy, and there is no preventive method for chromosomal diseases. For those who have suspicious chromosome disease, the chromosome should be checked before marriage, and the marriage of close relatives can be avoided, which can reduce the acquisition rate of the disease. Early detection, early diagnosis and early treatment also have an indirect preventive effect on the complications of the disease.

Sebaceous cyst disease complications Complications

Most of the disease is autosomal dominant hereditary disease, and secondly it may have certain correlation with environmental factors, dietary factors, and mood and nutrition during pregnancy. Therefore, patients with this disease may also have other chromosomal abnormalities, such as increased defects in G-6PD, patients may be complicated by "faba bean disease", hemolysis may occur when eating broad beans and their products.

Symptoms of sebaceous cyst disease Common symptoms Nodular cyst

For multiple, cystic nodules of different sizes, ranging from a few millimeters to 20mm or more in diameter, with a pale skin, light blue or yellowish surface, smooth surface, soft or hard nature, can be pushed, and it is good for the chest. Axillary fossa, upper arm, abdomen, scrotum, etc., severe cases can be systemic, except for palmar palpebral, occasionally see a single hair, called single fat sac tumor, can discharge oily or cheese-like liquid during puncture, some still See the discharge of small hair, usually in adolescence, suggesting that it is controlled by androgen, generally no symptoms.

Examination of sebaceous cyst disease

Histopathology: The wall of the capsule is wrinkled and composed of several layers of epidermal cells. Only 2 or 3 layers of squamous cells can be seen in the atrophy of the wall. The basal cells in other parts are arranged in a grid, and there are 2 to 3 layers of swollen cells. Unrecognized intercellular bridges, these cells have a thick homogeneous eosinophilic stratum corneum, irregularly extending into the lumen, similar to the decapitation of the apocrine sweat glands, and most of the cyst walls or adjacent to it, flattened sebaceous glands The leaflets are characteristic tissues of the disease. In addition, the hair roots and/or sweat glands are connected to the wall of the capsule. An amorphous oil composed of sebum tissue can be seen in the cyst cavity, and occasionally clustered manes are seen.

Diagnosis and identification of sebaceous cyst disease

diagnosis

Diagnosis can be performed based on clinical performance and laboratory tests.

Differential diagnosis

The disease should be differentiated from multiple subcutaneous lipomas. The appearance and the texture of the mass are similar to those of lipoma, so it should be identified. Lipoma is due to the abnormal proliferation of adipose tissue, so the texture is soft, B-ultrasound can be seen with adipose tissue, pathological biopsy can determine the pathological type of the mass, and the differentiation of sebaceous cyst is not difficult.

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