Diphenhydramine poisoning

Introduction to Diphenhydramine Poisoning Diphenhydramine is a commonly used antihistamine drug, and children's diphenhydramine poisoning (benadrylpoisoning) is caused by accidental or misuse of large doses, and the lethal dose is about 40 mg/kg. Occasionally, those who have an allergic reaction at a therapeutic dose. The toxic effect of diphenhydramine over a large dose is to inhibit the nerve central system first, followed by excitement, and then into inhibition, poisoning sick children have drowsiness, dizziness, headache, tinnitus, weakness, dry mouth, nausea, vomiting, constipation Frequent urination, redness on face and skin, irritability, nervousness, auditory hallucinations, confusion, muscle tremors, movement disorders, convulsions, dilated pupils, visual impairment, decreased blood pressure, tachycardia and other arrhythmias, severe illness due to breathing Paralysis or circulatory failure to death, children are prone to high fever and convulsions, often without pre-excitation inhibition, a few cases of generalized itching, rash, hemolytic anemia, neutropenia, dysosmia and so on. basic knowledge The proportion of the disease: the incidence rate is about 0.002% - 0.005%, more common in long-term oral diphenhydramine Susceptible people: good for children Mode of infection: non-infectious Complications: nausea and vomiting, anaphylactic shock, arrhythmia

The cause of diphenhydramine poisoning

Diphenhydramine poisoning is mainly seen in people who are excessively large or have eaten diphenhydramine.

Diphenhydramine poisoning prevention

1. Patients with bronchial asthma may have sputum viscous after taking diphenhydramine, which is difficult to cough up and aggravate breathing difficulties.

2. Hypotension, hypertension, other cardiovascular diseases, hyperthyroidism, glaucoma patients with caution.

3. Early pregnancy women, lactating women, newborns and premature babies are hanged.

4. Long-term application of this drug may cause hemolysis or hematopoietic dysfunction, especially for long-term injection.

5. Although antihistamines are antiallergic drugs, they can cause allergies themselves. Diphenhydramine has a case of drug allergic rash. Therefore, if the patient has a rash during the treatment, the drug will be discontinued or other antibiotics will be used. Histamine drugs.

6. Diphenhydramine can be avoided if it is combined with hypnosis, sedation, and stable drugs, or drinking at the same time can aggravate central inhibition.

7. Antihistamines often have rapid tachyphylaxis, or drug-resistant reactions. For example, when diphenhydramine is used in patients with habitual allergic disease, the initial efficacy is often very significant, but with the prolonged administration time, The effect is gradually reduced. When such drug-resistant reactions occur, it is advisable to switch to other types of antihistamines as early as possible to prevent the development of drug resistance from affecting the efficacy.

Diphenhydramine poisoning complications Complications, nausea and vomiting, anaphylactic shock, arrhythmia

1. The most common ones are: stagnation, sleepiness, lack of concentration, fatigue, dizziness, dizziness, ataxia, nausea, vomiting, loss of appetite, dry mouth and so on.

2. Uncommon are: shortness of breath, chest tightness, cough, dystonia, etc. It has been reported that after the administration, the jaw can be closed and accompanied by throat, anaphylactic shock, arrhythmia, excessive application can cause acute poisoning, mental disorders.

Symptoms of diphenhydramine poisoning Common symptoms Nausea arrhythmia Dizziness, sleepiness, tinnitus, convulsions, paralysis, urinary frequency, visual impairment

The excessive toxicity of this product is to inhibit the nerve central system first, followed by excitement, and then into the inhibition. The poisoned children have lethargy, dizziness, headache, tinnitus, weakness, dry mouth, nausea, vomiting, constipation, frequent urination. Redness on the face and skin, irritability, nervousness, auditory hallucinations, confusion, muscle tremors, movement disorders, convulsions, dilated pupils, visual impairment, decreased blood pressure, tachycardia and other arrhythmias, severe illness due to respiratory paralysis or Circulatory failure is fatal, children are prone to high fever and convulsions, often without pre-excitation inhibition, a few cases of generalized itching, rash, hemolytic anemia, neutropenia, olfactory disorders.

Examination of diphenhydramine poisoning

Patients who are poisoned should be taken to the hospital immediately for vomiting, gastric lavage, catharsis, intravenous rehydration, oxygen inhalation and symptomatic treatment. After the condition is stable, they should be routinely examined.

Diagnosis and identification of diphenhydramine poisoning

Identification of the detoxification of derivatives of ethanolamine.

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