Bowen's disease

Introduction to Bowen's disease Bowen's disease, also known as intraepithelia inoplasia, was first described by the American dermatologist Bowen as a precancerous keratosis. Pathologically, the name of the keratoconjunctival epithelial cancer is the most accurate. basic knowledge The proportion of illness: 0.003% Susceptible people: no specific people Mode of infection: non-infectious complication:

Cause of Bowen's disease

(1) Causes of the disease

According to the characteristics of the disease, it is suggested that the carcinogenesis of keratoconjunctival cells may be related to the irradiation of ultraviolet rays.

(two) pathogenesis

Factors such as ultraviolet radiation can damage intracellular DNA. When DNA repair is delayed or repair fails, normal epithelial cells can be cancerous and converted into tumor cell type development.

Bowen disease prevention

Pay attention to eye protection during production operations.

Bowen's disease complications Complication

No special complications

Bowen's disease symptoms Common symptoms Corneal or ulcer corneal epithelial erosion corneal burns

More common in men over the age of 60, the tumor is diffusely growing, the appearance is gray-red rubber-like flat bulge (rarely granulated), rich in blood vessels, and there is a clear boundary between the adjacent normal tissue, the touch is rough, Most of the tumors are located in the cleft palate, starting from the limbus, and extending to the conjunctiva and cornea (Fig. 1), but the multi-directional conjunctival invasion, only a few millimeters to the cornea, is often mistaken for chronic granulation tissue, sometimes in The original inflammation, wounds or burns occur on the lesion and have been neglected for a long time. Under the slit lamp, the tumor and the normal tissue are clearly defined. Most of the epithelium is loosened by pine needles or stained. The cancerous cells are found to be cancerous epithelial tissues. Although the lesions have been prolonged for many years, they only invade the superficial part of the cornea under the slit lamp. The cut surface of the stroma is clear and sharp, and there is no obvious signs of inflammation in the clinic.

The tumor develops slowly and is relatively static. It can be confined to the epithelium within a few years, but it may suddenly develop into a malignant tumor. Some patients have distant metastasis and local lesions have no obvious changes. It should be emphasized that some patients are in the body. There are also mucosal leukoplakia or organ cancer at the site.

Bowen's disease check

Pathological examination: It can be seen that the epithelial cells in the tumor site are consistently hyperplasia, and the spine cells are round or oval, varying in size, with obvious polarity disorder and nuclear mitosis, and the boundary between the proliferating epithelium and the normal epithelium is distinct. Tumor cells are confined to the epithelium without breaking through the basement membrane. The intact and clear basement membrane is the main distinguishing point between this disease and squamous cell carcinoma (Fig. 2, 3). Another important feature is the tumor with singular nucleus. The cell has a large and dense nucleus. Compared with normal cells, the nucleus of cancer cells occupies a large proportion of the whole cell, and the cytoplasm is less. It can also appear as a multinuclear giant cell in which several nuclei are clustered together. Shaped megakaryocytes or multinucleated cells can occur at various levels of the epithelium.

There are lymphocytic infiltration and neovascularization under the epithelium where the tumor is located. Some hyperplastic tumor cells have obvious nucleoli. The cytoplasm is stained with eosin, and there are many new blood vessels. The surface of the tumor has keratinized cells, but the complete pre-elasticity is visible. membrane.

No special auxiliary inspection.

Bowen disease diagnosis and identification

According to the growth characteristics and external manifestations of the tumor, the diagnosis depends on the pathological examination.

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