Geomycosis

Introduction to Geotricaria Geoticosis (Geotrichosis) is an occasional cause caused by the pathogenic fungus Candida, which is a yeast-like fungus that is widely distributed and can be parasitic on soil, vegetables and fruits, most often affecting the lungs and intestines. Road. In 1842, Beneff first reported that the disease was a measles disease in patients with tuberculosis. Because this disease is a conditional pathogenic infection, this disease is often associated with or secondary to tuberculosis, diabetes, leukemia and other wasting diseases or associated with long-term use of hormones and AIDS patients, often manifested as bronchial and pulmonary infections, Intestinal infections, etc., are more common in patients with severe immunodeficiency. basic knowledge The proportion of illness: 0.005% Susceptible people: no special people Mode of infection: contagious complication:

Cause of Geotricaria

(1) Causes of the disease

Geotricel disease is caused by the pathogenic bacteria Candida rhizogenes, most often affecting the lungs and intestines.

(two) pathogenesis

This disease is often associated with or secondary to tuberculosis, diabetes, leukemia and other consumptive diseases or associated with long-term use of hormones and AIDS patients, often manifested as bronchial and pulmonary infections, intestinal infections, etc., more common in patients with severe immunodeficiency .

Geotrice prevention

Primary prevention

(1) Separate susceptible patients with filtered air or laminar air to prevent cross-infection in hospitals.

(2) Control of diabetes, lymphoma and leukemia patients, strict control of immunosuppressive agents, cytotoxic drugs, anticancer agents, etc., have a certain preventive effect.

(3) Strengthen food management and prevent fungal pollution.

2. Secondary prevention Because the disease is very urgent and serious, early diagnosis is extremely important. Because mucormycosis is often difficult to detect in secretions, and it is difficult to identify, early diagnosis mainly relies on clinical evidence: that is, the disease is urgent, the condition is fierce, and the disease site The first is the nasal brain, followed by the chest, abdomen, pelvis, stomach and skin. The pathogenic factors are acidosis of diabetes, leukemia and lymphoma of lung infection, malnutrition of intestinal infection, such as protein deficiency in children, etc. Combined with clinical manifestations, laboratory (including fungal culture) and pathological examination (secretion, extracts, scrapings, etc.), rapid diagnosis may be achieved. Once diagnosed, amphotericin B should be used immediately, and 1.2 mg/kg should be administered every other day. If there is diabetes, it should be controlled immediately. The nasal cavity is used for surgical debridement. There are also advocated combination therapy. In addition to amphotericin B, 5-Fc, itraconazole or fluconazole are added.

3. Three-stage prevention and timely use of amphotericin B can reduce the mortality rate of this disease from 80% to 90% to about 50%. Control of diabetes and surgical necrosis of nasal necrosis can improve the prognosis of this disease.

Geomycosis complications Complication

Gastrointestinal mycosis is clinically similar to gastroenteritis, with stomach pain and diarrhea, and needs to be differentiated from candida or amoebic dysentery. Oral mycosis is clinically similar to oral candidiasis.

Symptoms of Geotricaria Symptoms Common symptoms Diarrhea Candida infection Hemophilia Stomach pains Granuloma squamous sputum with black eschar

1. Pulmonary mold disease clinical manifestations like pulmonary tuberculosis and often secondary to tuberculosis, manifested as fever, chronic cough, cough and hemoptysis, X-ray examination showed a tight infiltration, bronchial mold disease does not affect the lungs, symptoms like bacterial Or candida bronchitis, no fever but cough and bloody mucus-like sputum, X-ray examination showed diffuse thickening around the bronchi.

2. Gastrointestinal mycosis is clinically manifested as gastroenteritis with stomach pain and diarrhea, and needs to be differentiated from candida or amoebic dysentery.

3. The clinical manifestations of oral mycosis are similar to oral candidiasis. The genus Oryzae is a normal flora of the mouth, tongue and sputum. It is characterized by a clearly defined cheese-like plaque, a curd-like white pseudomembrane, and the pseudomembrane is removed. , left erythematous base, with burning sensation, throat, throat and their joints can be affected.

4. Dermatophytosis of the skin Most dermatophytosis affects skin folds, under the breast, groin and gluteal cleft, the most common erythema and exudation, and the stratum corneum peeling, often itchy, the disease is very Like skin wrinkle candidiasis, rarely affects soft tissue, once it is spread, it is neoplastic, nodular, granulomatous damage, rarely affects the bone, skin lesions can affect all parts of the body, especially the face, hands and trunk, with obvious Itching pain.

Examination of geotricemia

Direct inspection: sputum, feces, exudate, scales with 10% KOH smear visible fine separation of hyphae, sometimes visible joint spores, which is easily confused with dermatophytes and candida species.

1. Histopathological HE staining can be seen in the dermis, especially in the subcutaneous striated muscle vascular proliferation, surrounded by focal and diffuse cell infiltration; Langhans cells, epithelioid cells, lymphocytes, plasma cells, eosinophil infiltration, part Fibrosis, the formation of mixed cell granuloma, scattered and clustered 7 ~ 10m round spores and a few joint spores between the infiltrating cells, PAS staining is very obvious, 2 ~ 10m in size, individual round, cell The wall is thickened.

2. X-ray examination of lung and bronchial mycosis should be confirmed by X-ray examination.

Diagnosis and diagnosis of Geotricaria

The clinical manifestations of ear mold disease are Aspergillus or Candida infection, characterized by edema, erythema, epithelial exfoliation and crusting. The main symptoms are itching. Direct examination: sputum, feces, exudate, scales visible with 10% KOH smear Finely separated hyphae, sometimes visible joint spores, X-ray examination: lung and bronchial mycosis should be confirmed by X-ray examination.

Gastrointestinal mycosis is clinically similar to gastroenteritis, with stomach pain and diarrhea, and needs to be differentiated from candida or amoebic dysentery.

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