cerebrospinal fluid-bound myelin basic protein

MBP is synthesized in oligodendrocytes. It consists of 170 amino acid residues with a molecular weight of 18,000 and is rich in lipids. The protein content is about 30%, and MBP is a component of nerve tissue. After nerve tissue damage, CSF is released within a few days. Therefore, the increase in MBP concentration in CSF can reflect the destruction of neuromyelin integrity. Basic Information Specialist classification: neurological examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: normal. Normal value: Cerebrospinal fluid MBP: 0-1.59 μg / L Above normal: Found in central nervous system nerve tissue trauma, sporadic encephalitis, multiple sclerosis, brain tumor, cerebellar infarction, lateral medullary infarction, hypoxic encephalopathy; adrenal subacute sclerosing panencephalitis, viral encephalitis, hereditary White matter dystrophy, white matter atrophy, metachromatic leukodystrophy; transverse myelitis combined with systemic lupus erythematosus, lupus erythematosus and cranial nervous system, pons cerebral medulla, medullary pterygoid. negative: Positive: Tips: The examinee should stop taking the medicine. Normal value 0.73 ± 0.86 μg / L. Clinical significance Abnormal result Increased MBP: central nervous system nerve tissue trauma, sporadic encephalitis, multiple sclerosis, brain tumor, cerebellar infarction, lateral medullary infarction, hypoxic encephalopathy; adrenal subacute sclerosing panencephalitis, viral encephalitis , hereditary white matter dystrophy, white matter atrophy, metachromatic leukodystrophy; transverse myelitis with systemic lupus erythematosus, lupus erythematosus and cranial nervous system, pons cerebral medulla, methotrexate disease. People who need to be tested Sudden high fever, disturbance of consciousness, headache, strong neck, upper limbs and neck and scapular tendon symptoms. High results may be diseases: sporadic encephalitis, systemic lupus erythematosus caused by spinal cord disease Before taking the test: The examinee should stop taking the medicine. At the time of extraction: the examinee relaxes his body and eliminates the anxiety and anxiety. Not suitable for the crowd: no. Inspection process The cerebrospinal fluid of the examinee was taken, and the supernatant was taken by centrifugation after CSF. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.

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