Cerebrospinal fluid protein quantification

Cerebrospinal fluid protein quantification helps to reflect changes in protein content in different diseases of the central nervous system. Increased protein content in cerebrospinal fluid may suggest different types of central nervous system diseases. Basic Information Specialist classification: neurological examination classification: cerebrospinal fluid examination Applicable gender: whether men and women apply fasting: fasting Tips: Cerebrospinal fluid specimens are sent for inspection immediately after collection. If they are placed for too long, the test results will be affected. Normal value Adult lumbar pool 150 ~ 450mg / L, cerebellar medullary pool 150 ~ 250mg / L, intraventricular 50 ~ 150mg / L; Newborns 400 ~ 1200mg / L; The elderly are 300 to 600 mg/L. Clinical significance Increased protein content in cerebrospinal fluid may suggest different types of central nervous system diseases. Cerebrospinal fluid protein content of various central nervous diseases: Disease protein (mg/L); Bacterial meningitis 800 ~ 5000; Cryptococcal meningitis 250 to 2000; Viral meningitis 300 to 1000; Encephalitis 150 to 1000; Tumor 150~2000 (normally normal); Spinal cord tumor 1000~2000; Cerebral hemorrhage 300 ~ 1500; Neurosyphilis 500 ~ 1500; Multiple sclerosis 250 ~ 500; Tuberculous meningitis 500 ~ 3000; Brain abscess 200 ~ 1200; The inflammatory response after spinal cord disease is slightly increased. High results may be diseases: arachnoiditis, brain abscess, spinal cord tumor, new cryptococcal meningitis considerations The cerebrospinal fluid specimens are sent for inspection immediately after collection. If they are placed for too long, the test results will be affected: if the cells are denatured and destroyed, the counting and classification will be inaccurate; some chemical substances such as glucose will reduce the decomposition content; the bacteria will cause autolysis to affect the detection rate of bacteria. . After the cerebrospinal fluid is extracted, three sterile tubes are generally divided. The first tube is used for bacterial culture, the second tube is used for chemical analysis and immunological examination, and the third tube is used for general traits and microscopic examination. The order of the three tubes should not be reversed. Due to the difficulty in collecting specimens, all inspection and testing procedures should be safe. Inspection process The protein in the cerebrospinal fluid reacts with the sulfosalicylic acid-sodium sulfate reagent to produce an insoluble protein salt which is turbid, and its turbidity is directly proportional to its protein content. Not suitable for the crowd 1. If there is obvious papilledema or cerebral palsy, contraindications are contraindicated. 2. Patients who are in shock, exhaustion or endangered state and local skin inflammation, and lesions in the posterior cranial fossa are contraindicated. Adverse reactions and risks If the patient has symptoms such as breathing, pulse, or abnormal color during puncture, stop the operation immediately and deal with it accordingly.

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