Anti-Streptococcal M-Protein Antibody

Group A, hemolytic streptococcus 1, 3, 5, 9, 19, 24 cell wall contains more M protein, has anti-phagocytic effect, can cause strong immune response, M protein on the cell wall of streptococcus and human myocardial tissue It has cross-antigenicity and can stimulate the body to produce anti-streptococcal M protein antibody after infecting group A hemolytic streptococcus. This antibody can cause rheumatic carditis by acting on myocardial tissue. The study found that the gene pattern between the group A hemolytic streptococci (GAS)-induced rheumatic fever type strain and the nephrit-induced strain is different, and the rheumatoid-heat type GAS is almost all A, B, C gene patterns; GAS is almost entirely in the D, E gene model. It has been found that the M protein contains three repeats, which are divided into three regions: A, B, and C. The M regions of different M types are highly variable, while the C region is highly conserved. Therefore, the C region of the M protein is considered to be GAS. Rheumatoid-heat strains cause a common antigenic determinant of rheumatic fever and rheumatic heart disease. This antibody can be detected by ELISA. Basic Information Specialist classification: Infectious disease examination and classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Found in rheumatic fever and rheumatic heart disease. Tips: Hypercholesterolemia, multiple myeloma and macroglobulinemia can increase the anti-M protein antibody; anti-M protein antibodies can also be elevated when patients use a large number of antibiotics or hormones in the early stage of the disease. Normal value The anti-M protein C region antibody was <1.5 μg/mL. Clinical significance (1) The study found that anti-M1, M3, M5, M4, M19 and M24 antibodies were significantly elevated in patients with rheumatic fever and rheumatic heart disease. (2) The recombinant M protein C region was used as the coating antigen, and the anti-M protein C antibody in the serum of the patient was determined by ELISA. The result was significantly higher in the rheumatic fever group than in the healthy control group, indicating the presence of rheumatic fever in patients. Higher anti-M protein C region antibody. Precautions Patients with hypercholesterolemia, multiple myeloma, and macroglobulinemia may have elevated anti-M protein antibodies; anti-M protein antibodies may also be elevated when patients are treated with a large number of antibiotics or hormones in the early stages of the disease. Inspection process Same as ELISA. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.

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