Anti-single-stranded DNA (ssDNA) antibodies

Anti-ssDNA is one of anti-DNA antibodies that is less clinically important and less important than anti-dsDNA. DNA is a complex of macromolecules, a double helix formed by two nucleotide chains. Hydrogen bond cleavage between bases upon heating, and DNA denaturation produces ssDNA. The anti-ssDNA reaction site is mainly a base composed of purines and pyrimidines on ssDNA. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Indicates that rheumatic diseases may be present. Tips: The results should be combined with clinical analysis and should be regularly observed when necessary. Normal value negative. Clinical significance Anti-ssDNA assay results lack disease specificity, except for SLE patients with a high detection rate (50% to 60%), other rheumatism such as mixed connective tissue disease (MCTD), drug-induced lupus, hard skin Disease, dermatomyositis, Sjogren's syndrome, rheumatoid arthritis, etc. also have a detection rate of 10% to 70%. When the anti-dsDNA is negative and the diagnosis of SLE is not clear, the presence of high titer anti-ssDNA is also useful for diagnosis. Because many anti-DNA antibodies present in the serum of SLE patients can simultaneously react with dsDNA and ssDNA, indicating that they have the same epitope, it is considered that anti-ssDNA can not be ruled out, and even lead to renal pathology. Precautions The results of the measurements should be combined with clinical analysis and, if necessary, periodically observed. Inspection process Same as dsDNA detection. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.

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