Anti-U1RNP antibody

Like the Sm antigen, U1RNP (U1 ribonucleoprotein) is also an extractable nuclear antigen (ENA). In 1972, Sharp et al reported a new group of rheumatism, called mixed connective tissue disease (MCTD), in which anti-U1RNP antibodies were found in the serum of this group of patients. Its target antigen consists of U1snRNA with 70kD, A, C and a small amount of B'/B, D, E, F, G and other proteins, which are also involved in the cleavage of mRNA precursors. It has also been demonstrated that anti-U1RNP antibodies can enter living lymphocytes, interfere with cellular functions, and induce apoptosis. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: not fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: Tips for rheumatic diseases. Tips: If there is local congestion, use a warm towel after 24 hours to promote absorption. Normal value Normal human anti-U1RNP antibodies are negative. Clinical significance Anti-U1RNP autoantibodies can be detected in the blood of patients with various rheumatic diseases. The positive rate of SLE patients is 30% to 50%, systemic progressive sclerosis (PSS) is 25% to 30%; dermatomyositis 10% to 20% %, rheumatoid arthritis 5% to 10%, and in patients with mixed connective tissue disease (MCTD), high titer anti-U1RNP antibody detection rate can reach 100%, these patients often have no other specific autoantibodies Therefore, high titers of anti-U1RNP (especially high titer anti-70kD) antibodies are considered to be diagnostic markers for MCTD. Anti-U1RNP antibody (anti-70kD) positive is associated with myositis, esophageal motor dysfunction, and Raynaud's phenomenon, but most patients do not have nephritis. Precautions The advantage of immunoblotting is that 7 peptide antibodies can be detected at the same time, but the positive rate is not significantly improved compared with convection immunoelectrophoresis or agar double diffusion method (mainly because the target antigen is thermally denatured, so that it exists on the surface of the molecule). The epitope has changed). Therefore, the corresponding polypeptide antibody is negative and does not rule out the presence of certain rheumatism. Inspection process The same as the anti-Sm antibody assay. Not suitable for the crowd There are no taboos. Adverse reactions and risks There are no related complications and hazards.

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