tumor receptor imaging

Tumor receptor imaging is a technique that uses radionuclide-labeled receptor ligands to specifically bind to highly expressed receptors in tumor tissues, thereby showing imaging techniques for spatial distribution, density, and affinity of tumor receptors. It has high affinity and high specificity, radioactivity reaches the target, and blood clearance is fast, and tissue penetration ability is strong. Therefore, high contrast tumor images can be obtained in a short time, and almost no human immune reaction occurs. Basic Information Specialist Category: Oncology Inspection Category: Radionuclide Applicable gender: whether men and women apply fasting: fasting Tips: Please check the expedition to the department on the same day. Normal value The range of visualization is the receptor for a certain part of an organ or body. Clinical significance Abnormal results: Tumor somatostatin receptor imaging and treatment with positron-labeled octreotide such as 18F, 11C, copper [64Cu] and gallium [68Ga] have been used in thyroid cancer, gastrointestinal pancreatic nerve Endocrine tumors, pheochromocytoma, small cell lung cancer, etc. 18F, 68Ga and other labeled vasoactive peptides (VIP) have good biological activity, and are gastrointestinal VIP receptor-positive tumors (gastrointestinal pancreatic tumors), small cell lung cancer, meningioma, multiple pathological types of breast cancer, The diagnosis of high- or high-mortal tumors such as neuroblastoma provides a new and effective method. People who need to be examined: Tumor patients need to be examined, and they can also be checked for disease prevention. Precautions Forbidden before inspection: Please check the expedition to the department on the day of the examination. Requirements for examination: The patient should be at rest and use a sedative if necessary. Inspection process Radiolabeling methods: mainly direct labeling and indirect labeling methods. The direct method is to directly embed the radionuclide on the ligand or replace one of the elements by the redox method. For example, the commonly used chloramine T method iodine estrogen derivative. The indirect labeling method is mainly through the couplet. The agent is combined with a ligand and then complexed with a radionuclide, such as DTPA-conjugated octreotide, which can be combined with a radionuclide such as 111In, 90Y, 186Re, and 131I. Recently, some radioactive cesium-labeled peptides have been reported, but the methods are more complicated. Not suitable for the crowd Inappropriate people: Generally no special preparation is required. Adverse reactions and risks Nothing.

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