Tumor VIP receptor imaging

Vasoactive intestinal peptide (VIP) is a neurotransmitter composed of 28 amino acids with multiple functions, which regulates normal and tumor cell proliferation and differentiation through its receptor. VPAC (VIP receptor) is widely present in various normal and tumor tissues, but its expression density in tumor tissues is much larger than that in normal tissues, which lays a foundation for radionuclide-labeled vasoactive intestinal peptide receptor imaging. This imaging has been applied to the diagnosis, staging, treatment options and prognosis evaluation of a variety of tumors. Basic Information Specialist Category: Oncology Inspection Category: Radionuclide Applicable gender: whether men and women apply fasting: fasting Tips: Actively cooperate with the doctor during the examination. Normal value VIP is a polypeptide consisting of 28 amino acid residues, and the concentration in normal human serum is less than 20 pmol/L. Clinical significance Abnormal results: high density and high affinity VIP on tumor cell membranes such as intestinal adenocarcinoma and carcinoid, small cell lung cancer, breast ductal carcinoma, insulinoma, papillary thyroid carcinoma, dysothelioma, and pituitary adenoma secreting ACTH Body expression. Almost all of the well-differentiated gastrointestinal pancreatic endocrine tumors have VIP receptor expression, while in the undifferentiated such tumors, about half of them have VIP receptor expression. Based on this observation, the application of VIP receptor imaging to clinical preliminary results shows that the positive rate of VIP receptor radionuclide imaging in the same group of carcinoid and insulinoma patients is 92.9% (13/14 cases), and octreotide The positive rate of radionuclide imaging is very close to 90.9%. People to be examined: Patients with pancreatic carcinoids and related cancers or tumors need to be examined. Precautions Taboo before inspection: Generally no special preparation is required. Requirements for examination: Intravenous injection of tracer for 40 minutes after examination. Inspection process VIP receptors are highly expressed in many neuroendocrine and non-neuroendocrine tumors, and VIP receptor imaging is significantly more sensitive to gastrointestinal tumors than SST receptor imaging. Not suitable for the crowd Inappropriate crowd: Those who are allergic to the tracer. Adverse reactions and risks Nothing.

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