Carbon 13 urea breath test

The carbon 13 urea breath test is used to check the infection of Helicobacter pylori. The principle is to introduce the substrate labeled with stable nuclides 13C into the body (mainly oral), and the final metabolite 13CO2 of the substrate is detected by isotope ratio mass spectrometry. The changes are studied in the body's metabolic reactions and physiological processes. The carbon 13 urea breath test is a medical test used to detect Helicobacter pylori. Helicobacter pylori is a bacterium that can grow in the stomach, can cause gastritis, peptic ulcer, and is closely related to gastric cancer. Therefore, if it is detected early, whether it is infected or not, it will reduce gastrointestinal inflammation and ulceration. The opportunity for diseases. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: Determine the 12C/13C ratio (δ value) in the breath sample before and after taking the drug. If the delta value after exhalation minus the delta value before exhalation Positive: The 12C/13C ratio (δ value) in the breath sample before and after taking the drug was measured. If the difference between the delta value after exhalation minus the delta value before exhalation was >4, the Hp was positive, and the Helicobacter pylori was infected. Tips: The test must be done in the fasting state or two hours after the meal. Normal value The 12C/13C ratio (δ value) in the breath sample before and after taking the drug was measured. If the delta value after exhalation minus the delta value before exhalation was <4, it was Hp negative. Clinical significance Abnormal results: The 12C/13C ratio (δ value) in the breath sample before and after taking the drug was measured. If the delta value after exhalation minus the delta value before exhalation was >4, it was Hp positive, and then infected with Helicobacter pylori. Need to check the crowd: Aureus infection, patients with peptic ulcer. Positive results may be diseases: duodenal ulcer, pediatric peptic ulcer precautions Before the examination, the test should be carried out in the fasting state or two hours after the meal. The patient has not taken antibiotics, sputum preparations, proton pump inhibitors and other Hp sensitive drugs in the past month, otherwise it will cause false negative results. Taboo when checking: 1. Check in the morning. 2. Collect the first breath sample first, then take a special granule, sit still for 30 minutes, do not drink or eat anything during this time, and finally call the gas to another collection tube and collect it. The two tubes to the gas are analyzed on a specific instrument to obtain the presence or absence of HP. Inspection process (1) Oral cup of test meal (about 12ml); (2) collecting exhalation at zero hour; (3) Oral urea [13C], and start timing. (Dose: 75mg for adults, 13% abundance >99%, children: under 12 years old, 50mg, 13C abundance >99%); (4) Collect exhalations at 10, 20, 30, 40 and 50 minutes. In the simple method, only the 30th minute exhalation is collected. Not suitable for the crowd Not suitable for inspectors: None. Adverse reactions and risks No related complications or hazards.

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