Serum aspartase aminotransferase isoenzyme

AST has two isozymes, m-AsT present in hepatic cytoplasmic s-AST and hepatocyte mitochondria. s-AST is easily released into the blood, m-AST is tightly bound to the sub-structure of the cell and is difficult to release into the blood, so the serum s-AST accounts for 60% to 80%. In the case of mild to moderate hepatocyte damage, only soluble enzymes are released from the liver cytoplasm; if the liver cells are damaged or even necrotic, the enzymes in the mitochondria are also released. m-AST was used as an indicator of severe liver damage and hepatocyte necrosis. Basic Information Specialist classification: Digestive examination classification: liver function test Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value m-AST 2.8 ~ 6.2 U / L (inhibition method 37 ° C); m-AST accounts for 9.0% to 16.5% of AST (electrophoresis method). Clinical significance Elevated in viral hepatitis, chronic hepatitis, active cirrhosis, myocardial infarction, cardiomyopathy. High results may be diseases: aspartyl glucosamine, myocardial infarction, cirrhosis, cardiomyopathy, viral hepatitis, chronic hepatitis Note before the inspection: fasting for more than 12 hours. Inspection process 2 ml of fasting venous blood was taken and placed in a dry tube for examination to avoid hemolysis of the specimen. Continuous monitoring method for testing. Not suitable for the crowd Generally no taboos. Adverse reactions and risks 1. Infection: Pay attention to aseptic operation when collecting blood, avoid contamination of water and other parts at the blood collection site to avoid local infection. 2, bleeding: after the blood is given a full compression time, especially coagulopathy, bleeding tendency, to avoid local subcutaneous oozing, bruising and swelling.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.