Human Leukocyte Antigen B27 (HLA-B27)

Human leukocyte antigen B27 (HLA-B27) is a marker antibody for rheumatoid arthritis (RA) with high specificity and is diagnostic for early rheumatoid arthritis or rheumatoid arthritis with atypical clinical symptoms. HLA-B27 is closely related to ankylosing spondylitis (AS). 90% of AS patients have positive HLA-B27, while the positive rate in normal people is only 4%-7%. However, people who are not HIA-B27-positive will develop AS. According to statistics, about 20% of HLA-B27-positive people develop AS or other seronegative spondyloarthropathy, such as Reiter's syndrome, reactive arthropathy, and psoriasis joints. Sick and so on. Basic Information Specialist classification: growth and development check classification: immunological examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Normal value: no Above normal: negative: normal. Positive: The incidence of ankylosing spondylitis is high. Tips: Before the check-up taboo: Take the serum on an empty stomach in the morning and avoid eating. Normal value Generally negative. Clinical significance Abnormal results: Seronegative spondyloarthropathy is associated with HLA-B27. One of the common features is ankylosing spondylitis, which is the most strongly associated with HLA-B27. 90% of patients have positive HLA-B27, Reiter's syndrome HLA. The positive rate of “B27” is 37%-80%, and the positive rate of reflex arthritis is about 30%—77% of psoriatic arthritis and enterogenous arthritis with central axis joint involvement, HLA-B27 The positive rate can reach 30%, and the positive rate of HLA-B27 in rheumatoid joints is the same as that in normal people, about 4%-8%, so it has more important significance in the differential diagnosis of these diseases. People to be examined: Patients with ankylosing spondylitis and rheumatoid arthritis can be examined as a basis for treatment. Positive results may be diseases: juvenile joints, severe spondylitis, ankylosing spondylitis, Reiter syndrome precautions Contraindications before the examination: the serum is taken on an empty stomach in the morning, and the diet is contraindicated. Requirements for inspection: Mix well immediately after sampling to avoid air bubbles, which can cause hemolysis. Maintain at room temperature, optimal temperature, not refrigerated or frozen. Inspection process According to the conventional venous blood sampling method, then the detection: using the chemical fluorescence method, combined with the sequence-specific technology, the sequence alignment is designed to design a pair of specific primers and a specific needle, which not only improves the detection sensitivity and accuracy, but also makes the detection simple. Quickly, the analysis is directly analyzed after the reaction is completed, and no electrophoresis is required. Not suitable for the crowd Inappropriate people: no special requirements. Adverse reactions and risks There are no related complications and hazards.

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