Factor VIII/Factor IX procoagulant activity

Factor VIII and Factor IX play a very important role in blood coagulation. The disease caused by factor VIII deficiency, hemophilia A, is caused by a deficiency in factor IX. This assay is mainly used to determine the level of procoagulant activity of factor VIII and factor IX. According to the degree of decrease in procoagulant activity of factor VIII and factor IX, hemophilia A and B are classified as heavy (factor VIII procoagulant activity or factor IX procoagulant activity is less than 2%), medium (factor VIII procoagulant activity or factor IX) Procoagulant activity 2% to 5%), light (factor VIII procoagulant activity or factor IX procoagulant activity 5% to 25%), subclinical type (factor VIII procoagulant activity or factor IX procoagulant activity 25% to 45%) ). Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: More common in diseases such as hemophilia. Normal value: Factor VIII/Factor IX Procoagulant Activity: 87.3-128.7 Sub-IX procoagulant activity: 67.7-128.5 Above normal: More common in hypercoagulable state and thromboembolic disease. negative: Positive: Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value Factor VIII procoagulant activity was 103% ± 25.7%; sub-IX procoagulant activity was 98.1% ± 30.4%. Clinical significance Increased in 1, hypercoagulable state and thromboembolic diseases, especially venous thrombosis, pulmonary embolism, nephrotic syndrome, oral contraceptives for women, pregnancy-induced hypertension syndrome, malignant tumors. 2. Liver disease. Reduced in 1. Factor VIII procoagulant activity is mainly found in hemophilia A, von Willebrand disease and DIC. 2, factor IX procoagulant activity is mainly seen in hemophilia B, liver disease, vitamin K deficiency, DIC and so on. 3. According to the degree of decrease in procoagulant activity of factor VIII and factor IX, hemophilia A and B are classified into heavy (factor VIII procoagulant activity or factor IX procoagulant activity is less than 2%), medium (factor VIII procoagulant activity or Factor IX procoagulant activity 2% to 5%), light (factor VIII procoagulant activity or factor IX procoagulant activity 5% to 25%), subclinical type (factor VIII procoagulant activity or factor IX procoagulant activity 25% ~ 45%). Low results may be diseases: high results of pulmonary embolism may be diseases: hemophilia precautions First, the precautions before blood draw 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. Second, should pay attention after blood draw 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. 3. Please inform the doctor about the recent medication and special physiological changes before the test. Inspection process Blood is drawn, and blood is taken for examination. Generally, venous blood is taken, and blood is drawn by a doctor or a nurse. The amount of blood drawn is determined according to the difference of the test content and the number of items. The blood volume is usually 2-20 ml, and the maximum is not more than 50 ml. Not suitable for the crowd 1. Patients who have taken contraceptives, thyroid hormones, steroid hormones, etc., may affect the results of the examination and prohibit patients who have recently taken the drug history. 2, special diseases: patients with hematopoietic function to reduce disease, such as leukemia, various anemia, myelodysplastic syndrome, etc., unless the examination is essential, try to draw less blood. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye. 3, dizzy or fainting: in the blood draw, due to emotional overstress, fear, reflex caused by vagus nerve excitement, blood pressure decreased, etc. caused by insufficient blood supply to the brain caused by fainting or dizziness. 4. Risk of infection: If you use an unclean needle, you may be at risk of infection.

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