plasminogen

Plasminogen is a precursor of plasma fibrinolytic enzyme inactivity. Activation by a variety of enzymes in the tissue activator t-PA, urokinase or coagulation phase, and exogenous activators such as streptokinase can also be activated. Plasmin degrading fibrin and fibrinogen, keeping blood vessels and ducts clear, further studies found that plasmin function also includes collagenase activity and play a supporting role in nutrition and cell movement. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value Activity: 75-150%. Concentration: 0.06-0.25g/L. Clinical significance Lack of plasminogen can impair the body's ability to respond to clotting, such as clinically extensive thrombosis. This situation increases the risk of embolization after surgery or thrombolytic therapy. In other words, an increase in the concentration of plasminogen, once activated, can increase the risk of bleeding. Causes of plasminogen deficiency include hereditary defects, decreased liver synthesis, increased consumption (eg, DIC, sepsis, or thrombolytic therapy), as well as increased concentrations of plasminogen in tumor and diabetic patients. Precautions Since the concentration of plasminogen is more volatile, plasminogen is less sensitive to fibrinolytic assay than its inhibitor α2-antiplasmin assay. These two parameters are consumable indicators and can only indirectly reflect the actual fibrinolytic activity. Determination of plasmin-α2-antiplasmin complex (PAP) is more suitable. The chromogenic substrate method is simpler and faster, and is more suitable than immunochemical methods. In addition to a few type II defects, activity and antigen detection are well correlated. Inspection process Determination of activity by chromogenic substrate method Principle: Due to the action of streptokinase, plasminogen is completely converted to plasminogen activator (streptokinase-plasminogen complex) in plasma samples. The complex then hydrolyzes the chromogenic substrate and is measured by a spectrophotometer. The increase in absorbance is directly proportional to the plasminogen activity. Immunochemical method Gel electrophoresis, immunoturbidimetry, radioimmunoassay. Not suitable for the crowd No taboos. Adverse reactions and risks Risk of infection: If you use an unclean needle, you may be at risk of infection.

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