Qualitative determination of coagulation factor XIII

Factor XIII is a glycoprotein, also known as a fibrin stabilizing factor, derived from a variety of cells and liver in the bone marrow. Factor XIII is involved in the formation of thrombin, which plays an important role in the formation of a stable fibrin clot, which not only increases the resistance to fibrinolytic enzymes, but also facilitates wound healing. However, when factor XIII is deficient, insoluble fibrin cannot be produced and only soluble fibrin can be produced. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: It is forbidden to take anticoagulant drugs such as aspirin before testing. Normal value The fibrin clot did not dissolve within 24 hours. Clinical significance Abnormal result Clot dissolution within 24 hours Found in congenital and acquired coagulation factor XIII deficiency, such as liver disease, systemic lupus erythematosus, rheumatoid arthritis, lymphoma, specific liver cancer, pernicious anemia, uremia, multiple myeloma, leukemia, diffuse blood vessels Internal coagulation, primary fibrinolysis, etc. People who need to be examined have people who are prone to bleeding, fever, vomiting, poor wound healing, and erythematous rash. Precautions Before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. 4. It is forbidden to take anticoagulant drugs, such as aspirin, before testing. After inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process Inspection method: draw blood. Not suitable for the crowd Have a coagulopathy such as hemophilia. Adverse reactions and risks Discomfort: There may be pain, swelling, tenderness, and visible subcutaneous ecchymosis at the puncture site.

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