Thrombin depletion test

Under physiological conditions, blood coagulation requires the consumption of a large amount of prothrombin. After coagulation, there is little residual prothrombin in the serum, and the serum prothrombin time is significantly prolonged. If factors VIII, IX, XI, and XII are defective, thromboplastin production is poor. When prothrombin consumption is reduced, more prothrombin remains in the serum, and the prothrombin time is shortened. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: fasting Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. Normal value 24.9 ~ 108.2s (n = 50). >25s is normal, <20s is abnormal, and 20~25s is suspicious. Clinical significance Abnormal result CT shortening (<20s) 1 Hemophilia A, B and Factor XI, XII deficiency caused by deficiency of congenital factors VIII, IX, XI and XII. 2 Acquired factors VII, IX, XI and XII deficiency, such as DIC, primary fibrinolysis, liver disease, vitamin K deficiency and the like. 3 There are anticoagulant substances in the blood circulation, such as heparin, oral anticoagulant and other anticoagulant substances. 4 congenital and acquired PF3 deficiency, thrombocytopenia, thrombocytopenia, myeloproliferative syndrome, uremia and the application of antiplatelet drugs. People who need to be examined are prone to fever, vomiting, and bleeding. Low results may be diseases: hemophilia precautions Before inspection: 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. After inspection: 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. Inspection process Inspection method: draw blood. Not suitable for the crowd Hemophilia and diffuse intravascular coagulation. Adverse reactions and risks Dizziness or fainting: When blood is drawn, due to emotional overstress, fear, reflex caused by vagus nerve excitability, blood pressure drop, etc., the blood supply to the brain is insufficient to cause fainting or dizziness.

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