erythrocyte acetylcholinesterase

Erythrocyte acetylcholinesterase (CHE) is a hydrolase in lytic enzymes. Cholinesterase is divided into true cholinesterase (erythrocyte cholinesterase) and pseudocholinesterase (plasma cholinesterase). The former is derived from nerve cells and bone marrow erythroid cells, and is stored in nerve cells and neuromuscular muscles. In the junction and red blood cells, it decomposes acetylcholine, which accounts for 60% of whole blood cholinesterase; erythrocyte acetylcholinesterase is a good marker for synaptic function and atropine demand in patients with organophosphate poisoning. It can also predict the severity of the disease. When the erythrocyte cholinesterase activity reaches 30%, the muscles can work normally without the need for atropine treatment. When the erythrocyte cholinesterase activity is less than 10%, muscle dysfunction occurs and a large dose of atropine is required. Basic Information Specialist classification: cardiovascular examination classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Tips: Do not use the medicine before the inspection, the diet should be regular. Normal value Colorimetric method: 130 ~ 310U / L. Enzymatic method: children and adults male, female (over 40 years old) 5410 ~ 32000U / L; female (16 ~ 39 years old) 4300 ~ 11500U / L. Clinical significance Abnormal results: (1) Decreased erythrocyte acetylcholinesterase activity is common in paroxysmal nocturnal hemoglobinuria (PNH) and megaloblastic anemia, but the latter can return to normal after treatment. (2) increased in neurological diseases, hyperthyroidism, diabetes, hypertension, bronchial asthma, type IV hyperlipoproteinemia, renal failure and so on. Reduced in organic phosphorus poisoning, hepatitis, cirrhosis, malnutrition, pernicious anemia, acute infection, myocardial infarction, pulmonary infarction, muscle injury, chronic nephritis, dermatitis and late pregnancy, as well as intake of estrogen, cortisol, quinine, Morphine, codeine, theobromine, aminophylline, barbital and other drugs. Need to check the population of kidney failure, proteinuria, liver abnormalities, pernicious anemia and so on. Low results may be diseases: high diabetes results may be diseases: paroxysmal sleep hemoglobinuria precautions Unsuitable people: Most people can test. Before the test: Be careful not to take the medicine casually, and the diet should be regular. After the examination: not only to take medication on time, but also to maintain proper exercise, adjust the diet. Inspection process Inspection introduction: There are two types of cholinesterase, which can hydrolyze choline acetate. One type is acetylcholinesterase. The other type is hydroxycholinesterase. Cholinesterase is a hydrolase that acts to hydrolyze acetylcholine. Acetylcholine is a neurotransmitter released from the distal end of cholinergic nerves (such as parasympathetic nerves, motor nerves, sympathetic preganglionic fibers, etc.). When nerve endings are stimulated to cause excitement, acetylcholine is released, which binds to cholinergic receptors and exerts neuromuscular excitatory transmission. Subsequently, acetylcholine is hydrolyzed by cholinesterase to lose its effect. If the action of cholinesterase is inhibited, acetylcholine excess and agglomeration will occur, causing excessive excitation of cholinergic nerves and similar organophosphorus poisoning. Not suitable for the crowd No taboos. Adverse reactions and risks No complications.

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