hepatoma ferritin

Hepatoma ferritin (HF) is a ferritin isolated from liver cancer cells. Ferritin consists of 24 subunits of empty protein shells and 4,500 iron atoms. The 24 subunits of ferritin are divided into two types, H and L. The H subunit is larger, and the acidity is higher in myocardial ferritin; the L subunit is smaller, alkaline, and higher in hepatic ferritin. The ferritin has a molecular weight of about 450 kD. In the liver cancer cells, there is a special ferritin which is not found in normal liver cells and fetal liver in early pregnancy. The content of H subunit is high, acidic, and the isoelectric point is 5.1. This method uses a monoclonal anti-HF anti-HF establishment ELISA method. Basic Information Specialist classification: Digestive examination classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Tips: Do not eat liver, seafood, lean meat, sesame sauce before inspection. Normal value Serum: male (14.3 ± 10.9) μg / L, female (11.6 ± 7.O) μg / L. Clinical significance Abnormal results: Increased ferritin in liver cancer is seen in liver cancer, lung cancer, pancreatic cancer and breast cancer. The positive rate of serum ferritin was 67.7%, and the positive rate of lung cancer was 68.6%. Especially in the pre- or pre-treatment tests have more clinical value. Need to check the crowd: Preoperative detection of liver cancer, lung cancer, pancreatic cancer and breast cancer. High results may be diseases: liver cancer, pancreatic cancer considerations Requirements for inspection: Use fresh serum to avoid hemolysis and lipid interference. Can not eat before the test: liver, seafood, lean meat, sesame sauce. Not suitable for the crowd: there is no inappropriate crowd. Inspection process The expression of the gene was detected by RT-PCR, the expression of ferritin was detected by Western blot, and the amount of ferritin in the supernatant of the cell culture was determined. Finally, the magnetic resonance signals of four kinds of cells were detected, and the relationship between the expression of ferritin and magnetic resonance signals was analyzed. Not suitable for the crowd Have a coagulopathy such as hemophilia. Adverse reactions and risks Bleeding: Give sufficient compression time after blood collection, especially coagulopathy, bleeding tendency, avoid local subcutaneous oozing, bruising and swelling.

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