partial thromboplastin activity time

The activation of partial thromboplastin time is a more sensitive test for screening whether the endogenous coagulation system is normal. The simultaneous detection with prothrombin time is the main screening test combination of the second stage hemostasis. The test is mainly used for the detection of clotting factor deficiency in endogenous coagulation system, laboratory monitoring during heparin anticoagulant therapy, and detection of anticoagulant substances in lupus. Basic Information Specialist classification: growth and development examination classification: blood examination Applicable gender: whether men and women apply fasting: not fasting Tips: Do not take anticoagulants such as aspirin before testing. Normal value The test tube method was 37 ± 3 s. Clinical significance (1) prolonged (> normal value for more than 10s) diffuse intravascular coagulation (DIC), increased FDP (fibrin degradation products), factor VIII, IX, XI, XII factor deficiency, II, V Reduced factor X, treatment with anticoagulant (heparin, dicoumarin), reduction of anti-hemophilia globulin (AHG), reduction of plasma thromboplastin (PTC), plasma prothrombin precursor (PTA) cut back. (2) shortening the increase of factor VIII, factor V, DIC high blood coagulation period, thrombocytosis, poor venous puncture caused by mixed platelets in plasma. Low results may be diseases: hereditary coagulation factor V deficiency, hereditary coagulation factor XIII deficiency, hereditary coagulation factor VII deficiency considerations It is forbidden to take anticoagulants such as aspirin before testing. Inspection process (1) 0.109mol/L sodium citrate anticoagulant plasma 0.1ml, add 0.1ml of white clay partial thromboplastin suspension, shake well, incubate for 3min in 37°C water bath, gently shake it. (2) Add 0.1ml of 0.025mol/L calcium chloride solution, start the stopwatch at the same time, shake it in a 37°C water bath, take out the test tube at about 30s, observe the time of fibrin wire, and take the average twice. Not suitable for the crowd Those without examination indications should not be tested. Adverse reactions and risks 1, subcutaneous hemorrhage: due to pressing time less than 5 minutes or blood draw technology is not enough, etc. can cause subcutaneous bleeding. 2, discomfort: the puncture site may appear pain, swelling, tenderness, subcutaneous ecchymosis visible to the naked eye.

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