Serum Osteocalcin (BGP)

Osteocalcin is an active polypeptide synthesized and secreted by osteoblasts and plays an important role in regulating bone metabolism. Its level reflects osteoblast activity. Osteocalcin values ​​vary with age and bone turnover. The faster the bone turnover rate, the higher the osteocalcin value and vice versa. It plays an important role in regulating bone metabolism, and its level reflects osteoblast activity. Determination of serum osteocalcin is a reference index for the diagnosis of osteoporosis syndrome, rickets, metabolic bone disease, hyperthyroidism or hypothyroidism, and can also be used as an important indicator of bone metabolism in the elderly. Basic Information Specialist classification: inspection classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: The faster the bone turnover rate, the higher the osteocalcin value and vice versa. Normal value: Serum osteocalcin (BGP: 4.8-10.2ug/L Above normal: Elevation is seen in bone synthesis, especially in the early stage of bone synthesis after bone injury, postmenopausal osteoporosis, parathyroid osteoporosis. negative: Positive: Tips: Do not eat too greasy, high-protein foods the day before the blood draw, avoid heavy drinking. The alcohol content in the blood directly affects the test results. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. Normal value 4.8~10.2ug/L. Clinical significance Elevation is seen in bone synthesis, especially in the early stage of bone synthesis after bone injury, postmenopausal osteoporosis, parathyroid osteoporosis. In primary osteoporosis, postmenopausal osteoporosis is highly converted, so osteocalcin is significantly elevated; senile osteoporosis is low-transformation, so osteocalcin elevation is not obvious. Therefore, whether osteoporosis is high-conversion or low-transition type can be identified according to the change of osteocalcin. It should be noted that osteocalcin is significantly elevated in parathyroid osteoporosis. Low results may be diseases: high results of dense bone development disorders may be diseases: postmenopausal osteoporosis precautions First, the precautions before blood draw 1, do not eat too greasy, high-protein food the day before the blood, to avoid heavy drinking. The alcohol content in the blood directly affects the test results. 2. After 8 pm on the day before the medical examination, you should start fasting for 12 hours to avoid affecting the test results. 3, should relax when taking blood, to avoid the contraction of blood vessels caused by fear, increase the difficulty of blood collection. Second, should pay attention after blood draw 1. After blood is drawn, local compression is required at the pinhole for 3-5 minutes to stop bleeding. Note: Do not rub, so as not to cause subcutaneous hematoma. 2, the pressing time should be sufficient. There is a difference in clotting time for each person, and some people need a little longer to clotting. Therefore, when the surface of the skin appears to be bleeding, the compression is stopped immediately, and the blood may be infiltrated into the skin due to incomplete hemostasis. Therefore, the compression time is longer to completely stop bleeding. If there is a tendency to bleed, the compression time should be extended. 3, after the blood draw symptoms of fainting such as: dizziness, vertigo, fatigue, etc. should immediately lie down, drink a small amount of syrup, and then undergo a physical examination after the symptoms are relieved. 4. If there is localized congestion, use a warm towel after 24 hours to promote absorption. 3. Please inform the doctor about the recent medication and special physiological changes before the test. Inspection process 1. Take 10mm×75mm plastic tube and add sample reagent. 2. Add the PR separating agent, mix and put at 37 ° C for 30 min. After centrifugation for 15 min, the supernatant was discarded and radioactivity was measured in an automated gamma immunoassay. 3. Calculate the binding ratio of NSB and S0 by B/T, take B/B0Logit as the ordinate, the standard solution concentration as the abscissa, and get a corresponding straight line on the special coordinate paper. The concentration in the serum to be tested is directly determined by the sample tube B/B0Logit value. It can also be connected with a computer, automatically calculated under the control of special software, fitted with a standard curve, and printed out the sample OC concentration. Not suitable for the crowd no. Adverse reactions and risks no.

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