serum glyco-chenodeoxycholic acid

The principles of various plasma colloidal stability tests are basically the same, but all reagents are different, and the effects of promoting and inhibiting flocculation turbidity are different. Currently, clinical deoxycholic acid determination is also one of the commonly used. In the initial stage of acute viral hepatitis, when ALT and BiL have not reached the peak, CDCG and CG have risen sharply, indicating that serum CDCG and CG determinations are helpful for early diagnosis of acute viral hepatitis, and its apparently elevated mechanism is due to hepatocytes. In addition to its ingestion and excretion disorders, it may be related to intrahepatic bile stagnation. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Rare. Normal value: Male: 3.23 ± ± 1.52nmol / ml Female: 2.8-±1.45nmol/ml Above normal: Serum CDCG and CG determinations are helpful for early diagnosis of acute viral hepatitis. The mechanism of its apparent elevation may be related to intrahepatic biliary stagnation, in addition to hepatocyte uptake and excretion disorders. In chronic hepatitis, the serum CDCG content is still increased, CG/CDCG>1 or an upward trend, suggesting a better prognosis or improved liver function. negative: Positive: Tips: Before the examination, the diet is light and alcohol is prohibited. Check for an empty stomach in the morning. Normal value It has been reported in China that the fasting serum CDCGX±SD of 121 normal controls is 3.01±1.5 nmol/ml, and the 95% normal range is 0.46-5.9 nmol/ml. Male and female were 3.23±1.52nmol/ml and 2.8±1.45nmol/ml, respectively. The ratio of CG/CDCG is 0.34 to 1.22. Clinical significance CDCG is one of the main components of bile acids in human body, and its physical and chemical properties and metabolic pathways are similar to CG. 1. In the initial stage of acute viral hepatitis, when ALT and BiL have not reached the peak, CDCG and CG have risen sharply, indicating that serum CDCG and CG determination are helpful for early diagnosis of acute viral hepatitis. Hepatocytes may be associated with intrahepatic bile stagnation in addition to their ingestion and excretion disorders. 2. In chronic hepatitis, the serum CDCG content is still increased, and it is more valuable to observe the ratio of CG/CDCG. A CG/CDCG ratio of <1 indicates a poor prognosis. CG/CDCG>1 may have an upward trend, suggesting a better prognosis or improved liver function. The CG/CDCG ratio of chronic liver disease was lowest in cirrhosis, followed by chronic prolonged hepatitis. This suggests that the magnitude of CDCG elevation and the extent to which the CG/CDCG ratio is reduced are related to the severity of liver injury. High results may be diseases: viral hepatitis, liver damage, chronic hepatitis precautions Determining the ratio of glycosidic acid to glycodeoxycholic acid may have diagnostic value because about 80% of patients with hepatocellular disease have a ratio of <1, while in 80% of patients with cholestasis disease the ratio is >1. Inspection process 1. The serum is diluted 50 times with absolute ethanol, centrifuged to remove protein, and 0.1 ml is taken and evaporated to dryness. A series of standard tubes with different concentrations of CDCG standard tubes were also taken. 2. After centrifugation at 4 ° C (3500 r / min) for 15 min, remove the supernatant and measure the radioactivity of the precipitate (B). 3. Calculate the linear regression equation by LogitB/B0: the logarithm of the standard tube content, and calculate the sample amount according to this equation. Not suitable for the crowd no. Adverse reactions and risks no.

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