Serum Cholinesterase (CHE)

There are two types of cholinesterases, all of which hydrolyze choline acetate. One type is acetylcholinesterase. The other type is hydroxycholinesterase. Cholinesterase is a hydrolase that acts to hydrolyze acetylcholine. Acetylcholine is a neurotransmitter released from the distal end of cholinergic nerves (such as parasympathetic nerves, motor nerves, sympathetic preganglionic fibers, etc.). When nerve endings are stimulated to cause excitement, acetylcholine is released, which binds to cholinergic receptors and exerts neuromuscular excitatory transmission. Subsequently, acetylcholine is hydrolyzed by cholinesterase to lose its effect. If the action of cholinesterase is inhibited, acetylcholine excess and agglomeration will occur, causing excessive excitation of cholinergic nerves and similar organophosphorus poisoning. Serum cholinesterase is an indicator of the function of liver synthesis of proteins, and is mainly used to estimate the severity of liver disease and the diagnosis of amoebic liver disease. Basic Information Specialist classification: Digestive examination classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Pathological reduction is seen in severe hepatitis, chronic hepatitis active type, cirrhosis, liver abscess, various cancers, hypoproteinemia (nutrition, anemia, infection, dermatomyositis, acute myocardial infarction), hereditary serum CHE abnormalities, Organophosphorus poisoning (30% reduction in mild poisoning, 50% reduction in moderate poisoning, 70% reduction in severe poisoning), ulcerative colitis, renal insufficiency, pemphigus, burns, etc. Normal value: Enzyme rate method (37 ° C): 4300-10500U / L Above normal: Pathological elevation is seen in nephrotic syndrome, hyperthyroidism, diabetes, fatty liver, primary familial hyper-CHEemia, serum CHE mutation, and primary liver cancer. negative: Positive: Tips: Take 2ml of venous blood for 12 hours on an empty stomach, and separate the serum for measurement to avoid hemolysis. Elevation can also be seen in obese people, lower can also be seen in the hungry, late pregnancy, and after the intake of estrogen, hydrocortisone, quinine, morphine, codeine, theobromine, barbital and other drugs. Normal value 1. Enzyme rate method (37 ° C) 4300 ~ 10500 U / L. 2. The test paper method is 38-80 U/ml. 3, colorimetric serum 130 ~ 310U / ml, whole blood 8 ~ 120U / ml. (Note the specific reference value depends on each laboratory.) Clinical significance 1, pathologically elevated in nephrotic syndrome, hyperthyroidism, diabetes, fatty liver, primary familial hyper- CHE, serum CHE mutation, primary liver cancer. 2, pathological reduction seen in severe hepatitis, chronic hepatitis active type, cirrhosis, liver abscess, various cancers, hypoproteinemia (nutrition, anemia, infection, dermatomyositis, acute myocardial infarction), hereditary serum CHE abnormalities Symptoms, organophosphate poisoning (30% reduction in mild poisoning, 50% reduction in moderate poisoning, 70% reduction in severe poisoning), ulcerative colitis, renal insufficiency, pemphigus, burns, etc. Low results may be diseases: chlorpyrifos poisoning, nephrotic syndrome, fatty liver results may be high disease: fulminant hepatic failure, cirrhosis, liver abscess, hyperthyroidism 1. Take 2 ml of venous blood for 12 hours on an empty stomach, and separate the serum for measurement to avoid hemolysis. 2, elevated can also be seen in obese people, lower can also be seen in the hungry, late pregnancy, and intake of estrogen, hydrocortisone, quinine, morphine, codeine, theobromine, barbital and other drugs. Inspection process Take appropriate blood samples and immediately send them for inspection. Not suitable for the crowd Those without examination indications should not be tested. Adverse reactions and risks Risk of infection: If you use an unclean needle, you may be at risk of infection.

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