beta glucuronidase

Beta glucuronidase is a hydrolase in cell lysosomes and is high in hepatocytes. Determination of glucuronidase is helpful for disease observation and prognosis evaluation. Increased urinary β-Glucuronidase: acute renal failure, kidney and cervical or bladder cancer, glomerular disease, acute tubular necrosis, pregnancy, urinary tract infection, urinary tract injury, renal transplant rejection, renal tuberculosis, acute pyelonephritis , schistosomiasis, systemic lupus erythematosus (SLE) and workers engaged in aniline production. Basic Information Specialist classification: growth and development check classification: biochemical examination Applicable gender: whether men and women apply fasting: fasting Analysis results: Below normal: Severe liver failure and type VII mucopolysaccharidosis. Normal value: Male: 7.31-12.65U/L Female: 5.11 - 9.77U / L Above normal: Viral or toxic hepatitis (with hepatocyte necrosis), cirrhosis, and malignant tumors of the pancreas, breast, liver, colon, and cervix. Also seen in the third trimester of pregnancy. negative: Positive: Tips: Try to eat less and eat as much as possible, and arrange your diet reasonably. Normal value 1, customary units Male 998±267μg·h-1·dl-1 (n=20, ±s) Female 744±233μg·h-1·dl-1 (n=22,±s) 2, the legal unit Male 9.98±2.67U/L (±s) Female 7.44±2.33U/L (±s) 3, conversion factor Gg·h-1·dl-1×0.01=U/L U/L×100=μg·h-1·dl-1 Clinical significance 1. Serum β-glucuronidase raises viral or toxic hepatitis (with hepatocyte necrosis), cirrhosis, and malignant tumors of the pancreas, breast, liver, colon, and cervix. Also seen in the third trimester of pregnancy. 2, serum β-Glucuronidase decreased severe liver failure and type VII mucopolysaccharidosis. 3, urinary β-Glucuronidase rise acute renal failure, kidney and cervical or bladder cancer, glomerular disease, acute tubular necrosis, pregnancy, urinary tract infection, urethral injury, renal transplant rejection, renal tuberculosis, acute renal pelvis Nephritis, schistosomiasis, systemic lupus erythematosus (SLE), and workers engaged in aniline production. Low results may be diseases: high incidence of fulminant hepatic failure may be disease: precautions for viral hepatitis 1. Decrease factors of β-glucuronidase activity in serum and urine: Hg2+, Cu2+, Ag+, Ni2+, Zn2+, Sn2+. 2, serum β-Glucuronidase rising factors: androgen (synthesis phase), chlorpromazine, ethanol (acute alcoholic poisoning), estrogen, oral contraceptives. 3. Factors that increase urine β-Glucuronidase: protamine, proteinuria, and bacteriuria. 4, β-Glucuronidase enzymes are widely distributed, in which the enzyme activity in the liver is extremely high. There are three isozymes, and the optimum pH values ​​are: 3.8.4.5 and 5.2. Inspection process Colorimetry. Not suitable for the crowd no. Adverse reactions and risks no.

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