Pediatric aquatic histiocytosis

Sea blue histiocyte syndrome (sea blue histiocyte syndrome) is a class of autosomal recessive genetic diseases due to abnormal lipid catabolic enzymes. Due to reduced sphingomyelinase activity and accumulation of sphingomyelin and neuroglycolipid in affected tissues, bone marrow, liver, and spleen cells were named after the histochemical staining of sea-blue particles, beginning in 1970. Some people think it may be a variant of NPD.

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