Steroid 5α-reductase 2 deficiency syndrome

Any abnormality of androgen in the process of target cell action can cause the incomplete expression of androgen and male pseudohermaphroditism. Androgen's action process includes the reduction of testosterone by steroid 5alpha; -reductase 2 to DHT, the combination of testosterone and DHT with androgen receptor (AR), androgen mdash; the location and transcription of receptor complexes in hormone response elements . There are two main types of androgen resistance syndromes. The first is abnormal metabolism of testosterone in target cells, namely steroid 5alpha; -reductase 2 deficiency syndrome; the second is AR abnormalities, including testicular feminization and Reifenstein syndrome. .

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