Binswanger disease

Binswanger disease, also known as subcortical arteriosclerotic encephalopathy, is a more common type of small vessel dementia. Binswanger (1894) first reported a 54-year-old female patient with progressive mental retardation, speech impairment, weakness in both lower limbs and two-hand tremor, describing cerebral arteriosclerosis, significant enlargement of bilateral ventricles, white matter atrophy, and multiple ependymal enlargements Thick and other pathological changes. Alzheimer formally proposed the disease in 1902 and was named after his teacher Binswanger.

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