Osteomalacia and rickets

Osteomalacia and rickets are a type of skeletal disease characterized by newly formed bone matrix mineralization disorders. As a result, non-mineralized bone-like tissue (osteoid) accumulates and the bone softens, resulting in a series of clinical symptoms and signs such as bone pain, bone deformity and fracture. The etiology of the disease is diverse and can be divided into four categories: ① Vitamin D nutritional deficiency. ② Deficiency of the metabolic activity of vitamin D. ③ Deficiency of minerals in bone mineralization sites. ④ Bone cells and bone matrix disorders. Rickets occurs before puberty, that is, before the long bone growth plate is closed to the closed period. In adults, bone mineralization after the epiphyseal growth plate is closed is called osteomalacia.

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