Neonatal bilirubin encephalopathy

Bilirubin encephalopathy is the entry of free bilirubin through the blood-brain barrier into the central nervous system, which leads to degeneration of nerve cells and clinical and subclinical manifestations of neurological abnormalities. For decades, nuclear jaundice has been synonymous with neurotoxic manifestations of bilirubin. Strictly speaking, nuclear jaundice is an anatomical term. From the perspective of pathological anatomy, the naked eye sees brain tissue stained yellow as a standard for nuclear jaundice, thereby reflecting that bilirubin invades brain tissue (mainly the nerve nucleus). Recently, more and more studies have shown that the neurotoxicity caused by bilirubin is mild or severe. In severe cases, it can be manifested as nuclear jaundice. In mild cases, there are no clinical symptoms, but auxiliary examinations such as brain stem evoked potentials can be used. Find abnormal performance. Most of these subclinical bilirubin neurotoxicity manifestations are temporary and reversible, so they are also called transient subclinical bilirubin neurotoxicity.

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