Lactic acidosis

Lactic acid is reduced by pyruvate and is a sugar intermediate metabolite. It is reduced to lactic acid when O2 deficiency or pyruvate is not oxidized. Acidosis caused by elevated lactic acid levels for various reasons is called lactic acidosis. The lactic acid concentration in normal fasting venous blood (at rest) is 0.4 to 1.4 mmol / L, and the pyruvate concentration is 0.07 to 0.14 mmol / L. The ratio of the two is 10: 1, usually 15: 1, and it is usually in equilibrium; When the concentration of lactic acid exceeds 2mmol / L (some consider 5mmol / L), HCO-3 ≤10mmol / L, lactic acid / pyruvate 10 and other causes of acidosis can be ruled out, the diagnosis of this disease can be confirmed.

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