Organophosphate poisoning

Organophosphorus pesticides commonly used include paraben (3911), systemic phosphorus (1059), parathion (1605), dichlorvos, dimethoate, trichlorfon, and malathion (4049). The common causes of poisoning are direct skin contact, respiratory tract inhalation, misuse and misuse. Absorption through the skin progresses slowly; inhalation through the mouth and airways progresses rapidly. The toxicity of organophosphorus to humans and animals is mainly the inhibition of acetylcholinesterase, causing the accumulation of acetylcholine, causing continuous impulses of cholinergic nerves, leading to a series of muscarinic, nicotinic and central nervous systems, etc. Symptoms: Severe patients can die from coma and respiratory failure. Organophosphate insecticides are mostly oily or crystalline, with a color ranging from light yellow to brown, slightly volatile, and garlicky. Except trichlorfon, it is generally difficult to dissolve in water, not easily soluble in many organic solvents, and easily decomposes and fails under alkaline conditions. Commonly used dosage forms are emulsions, oils and powders. R and R 'are alkyl, aryl, hydroxylamine or other genes, X is alkoxy, propyl or other substituents, and Y is oxygen or sulfur.

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