Skin hemosiderin

Hemoflavin is an unstable ferritin polymer with a brown iron pigment. Intravascular hemolysis produces excessive free hemoglobin that is excreted by the kidneys and produces hemoglobinuria, some of which is reabsorbed and degraded by renal tubular epithelial cells to produce hemosiderin. If it exceeds renal tubular epithelial cell transport capacity, it is deposited in epithelial cells Cell shedding is excreted with urine, forming hemosiderin. Idiopathic melmomaryhae mosiderosis (IPH), a rare disease with intermittent pulmonary hemorrhage. More than 200 cases were reported internationally and more than 120 cases were reported domestically (by 1994). It is a rare disease with unknown etiology. The disease is characterized by diffuse alveolar hemorrhage and secondary iron deficiency anemia. No other organs were involved. As the pulmonary capillaries repeatedly bleed, the exuding blood is hemolyzed, in which the globin portion is absorbed, and the hemosiderin containing hemosiderin reacts in the lungs. Pathology showed increased lung weight. The cut surface has extensive brown pigmentation. Microscopic examination of alveolar and interstitial macrophages containing hemosiderin. There are varying degrees of diffuse fibrosis in the lungs, alveolar interstitial and vascular elastic fibrosis. Electron microscopy showed diffuse capillary damage with endothelial cell edema and protein deposition on the basement membrane. The disease occurs in children and young people, and clinical symptoms are related to pulmonary bleeding and duration. Paroxysmal or persistent cough, hemoptysis, and shortness of breath. The hemoptysis lasts for several hours or days, and gradually resolves on its own. At this time, except for pale and tired, it is basically asymptomatic, but it can recur after several weeks and months. Chest signs were normal. Due to anemia, cyanosis is often obscured. Severe patients are often accompanied by pulmonary heart disease or clubbing fingers. Massive hemoptysis is a common cause of death. X-ray of the chest shows scattered shadows of small nodules in the two hilums or inferior medial bands. In severe cases, it can be merged into frosted glass sheet shadows. Symptoms can be improved or even absorbed. Glucocorticoids for treatment can control bleeding, but can not stabilize the disease and prevent recurrence in the long term. In chronic cases, the effect is not significant. Iron can relieve severe anemia.

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