Pediatric aggressive glomerulonephritis

Rapidly progressive glomerulonephritis (RPGN) is a clinical syndrome that develops rapidly, from hematuria and proteinuria to oliguria or anuria to acute nephritis syndrome with acute renal failure. Clinically, renal function deteriorates rapidly, and the glomerular filtration rate (GFR) usually decreases by more than 50% within 3 months. The development of end-stage renal failure usually takes weeks or months. The disease progresses rapidly, the condition is critical, and the prognosis is poor. The pathological changes are characterized by cell proliferation and fibrin deposition in the glomerular sac, which are manifested by extensive crescent formation, so it is also called crescentic nephritis (CGN). The incidence of this group of diseases is low and the risk is high. Prompt diagnosis and adequate treatment can still effectively change the prognosis of the disease, which should be highly valued clinically. Although the prognosis of this disease is dangerous, with the improvement of its etiology and pathogenesis in recent years and the improvement of treatment methods, its prognosis has been greatly improved.

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