Multiple pinpoint petechiae

Introduction Multiple needle-like defects are mostly infectious mononucleosis. Infectious mononucleosis is an acute mononuclear-macrophage system proliferative disease, and the course of disease is often self-limiting. Epstein-Barr virus is the pathogen of this disease. The morphological structure of Epstein-Barr virus under electron microscope is similar to other viruses in the herpesvirus group, but the antigenicity is different. The Epstein-Barr virus is a DNA virus, and the intact virus particles are composed of a nucleus, a membrane shell, a shell particle, and an envelope. The nucleus contains viral DNA, and the membrane shell is a icosahedral stereo-symmetric shape composed of tubular protein subunits, and the envelope is derived from the host cell membrane. EB disease has extremely special growth requirements and is only propagated in cultures such as African lymphoma cells, blood cells of leaflets, leukemia cells, and healthy human brain cells, so virus isolation is difficult.

Cause

Epstein-Barr virus is the pathogen of this disease. The morphological structure of Epstein-Barr virus under electron microscope is similar to other viruses in the herpesvirus group, but the antigenicity is different. The Epstein-Barr virus is a DNA virus, and the intact virus particles are composed of a nucleus, a membrane shell, a shell particle, and an envelope. The nucleus contains viral DNA; the membrane shell is a icosahedral stereo-symmetric shape composed of tubular protein subunits; the envelope is derived from the host cell membrane. EB disease has extremely special growth requirements and is only propagated in cultures such as African lymphoma cells, blood cells of leaflets, leukemia cells, and healthy human brain cells, so virus isolation is difficult.

Epstein-Barr virus has six antigenic components, such as membrane-shell antigen, membrane antigen, early antigen (can be subdivided into diffuse component D and localized component R), complement-binding antigen (ie soluble antigen S), EB virus nuclear antigen, lymphocyte examination The membrane antigen (lymphacytedetectedmembranceantigen LYDMA), the first five can produce their respective antibodies, LYDMA has not yet detected the corresponding antibody.

an examination

Related inspection

Heterophilic agglutination test skin color

The sporadic cases are easily overlooked. The diagnosis is based on clinical symptoms, typical blood and positive heterophilic agglutination tests. In the future, the two are more important. When there is epidemic, epidemiological data has great reference value.

When it is difficult to carry out serological examination, a diagnosis can be made according to the combination of blood and blood. Although the clinical manifestations are more common with high fever, angina, and cervical lymphadenopathy, they are not necessarily. Serum alanine aminotransferase is mostly elevated in the course of the disease, even if there is no jaundice, it is worthy of attention. The typical blood and heterophilic agglutination test is altered or positive on the second day of the disease course, but significant changes are generally seen between weeks 1 and 2, and the heterophilic agglutination test even rises to a meaningful level after several months. It is important to emphasize the importance of repeated examinations. One or two negative results cannot be denied a diagnosis.

Differential diagnosis

Can be differentiated from mastocytosis, polycythemia.

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