Negative nitrogen balance

Introduction The intake of nitrogen is less than the discharge of nitrogen called negative nitrogen balance. This indicates that the amount of protein synthesized in the body is less than the amount of decomposition. This is the case with chronic wasting diseases, tissue trauma and hunger. Insufficient protein intake leads to weight loss, reduced resistance to disease, and difficulty in healing the patient's wounds. When the intake of amino acids is less than the consumed amino acids, symptoms such as malnutrition, back pain, dizziness, frailty, and metabolic deterioration are called negative nitrogen balance. That is, the amount of nitrogen ingested by food is less than the amount of nitrogen in the excreta, which is called negative nitrogen balance.

Cause

It is caused by increased metabolic hormones, loss of calories and protein, decreased digestion and absorption, and inadequate intake due to severe trauma or wasting disease.

an examination

Related inspection

Urea nitrogen urinary osmotic pressure

Clinical manifestations include weight loss, muscle atrophy, wound enlargement, wound nonunion, and plasma protein reduction.

Differential diagnosis

Differential diagnosis of negative nitrogen balance:

1. Nitrogenemia: Nitrogenemia is a biochemical term with two concepts in both broad and narrow sense. The broad concept is that as long as the blood urea nitrogen, non-protein nitrogen or creatinine is outside the normal range, it can be called azotemia. Various kidney diseases are prolonged and unhealed, and renal function damage may occur in the late stage, so that nitrogen leakage in the blood is blocked, and sputum accumulates in the blood, which is the result of renal failure. However, normal people eat high-protein foods in a short period of time, such as Chinese New Year holidays or too many banquets. Although the kidney function is normal, but the excessive nitrogen can not be quickly discharged in a short time, it will appear once. Sexual azotemia.

In addition, patients with nephrotic syndrome edema and oliguria may also have transient azotemia. When diuretics are applied, the amount of urine increases, and blood urea nitrogen will also fall to normal. This cannot be regarded as renal failure. There is no need for patients to carry heavy burdens of thought.

2, high blood nitrogen: high blood nitrogen refers to the proportion of nitrogen in the blood increased, this phenomenon is likely to occur when kidney function disorders.

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