Drug-induced seizures

Introduction Epilepsy due to drugs is called drug-induced epilepsy. Many drugs can cause seizures. Common drugs are isoniazid, insulin, lidocaine, phenformin, phenothiazine, chlorpromazine and the like. There are many types of clinical seizures in drug-induced epilepsy, among which the generalized tonic-clonic seizures are the most common. The occurrence of drug-induced epilepsy is affected by drug dose, combination therapy, central nervous system disease, and individual differences.

Cause

Common drugs are isoniazid, insulin, lidocaine, phenformin, phenothiazine, chlorpromazine and the like.

an examination

Related inspection

EEG examination of brain CT examination blood test

The time of occurrence of drug-induced epilepsy varies significantly between different drugs, and can occur during the course of administration, from a few minutes to several years after administration, when the drug is suddenly discontinued or changed.

For example: enflurane, ketamine, propylene alkyne, sodium barbital, when the drug is used or a few minutes after the drug appears;

Most of the isoniazid appeared in the attack for 2 hours; the immunization agent often occurred within 1 to 20 days after the administration;

Seizures caused by pentylenetetrazol and insulin may occur after 1 year of treatment; seizures caused by benzodiazepines and stimulants are similar to those of chronic alcoholism, and occur mostly during the withdrawal period after withdrawal.

In general, the longer the incubation period, the greater the likelihood of recurrence of epilepsy. The epilepsy that occurred within 2 weeks of termination of treatment, nearly one-quarter of patients re-emerged, and the recurrence rate was higher after more than 2 weeks.

Differential diagnosis

Seizures caused by other causes.

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