Hippocampal sclerosis

Introduction Hippocampal sclerosis is a special pathological change characterized by loss of hippocampal neurons and germination of mossy fibers. Studies have found that the loss of hippocampal neurons leads to synaptic reorganization of viable cells, resulting in abnormal cell synchronization and excitability, resulting in spontaneous seizures.

Cause

1. Early childhood risk factors: 66% of patients with hippocampal sclerosis have a history of febrile seizures in childhood, especially long-term febrile seizures are closely related to hippocampal sclerosis. Some patients have other history of early brain injury, including trauma and infection. Or hypoxic ischemic brain damage, etc.;

2, hereditary epilepsy susceptibility: the incidence of epilepsy in the MTLE family is higher, suggesting that it is associated with congenital genetic susceptibility, early risk factors such as febrile seizures or hypoxia can lead to cell loss and neuronal reorganization;

3, micro-dysplasia: in some hippocampal sclerosis patients can be found in hamartoma, neuronal ectopic or hippocampus itself structural dysplasia.

an examination

Related inspection

Neurological examination of brain CT examination of brain MRI

Can perform neurological examination, brain CT examination.

Differential diagnosis

It can be differentiated from neurosis associated with epilepsy.

Neuroses associated with epilepsy are common symptoms of clinical manifestations of mental disorders associated with epilepsy.

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