High glutamyl transpeptidase

Introduction -glutamyltranspeptidase (-GT) is widely distributed in human tissues, with the largest number of kidneys, followed by pancreas and liver, and the most in the liver during embryonic stage. It is mainly distributed in liver cytoplasm and liver. In the bile duct epithelium, -GT in normal human serum is mainly from the liver. The normal value is 3 to 50 U/L (-glutamyl p-nitroaniline method). This enzyme is only mildly elevated in acute hepatitis, chronic active hepatitis, and cirrhosis. However, when obstructive jaundice, the enzyme flows back into the blood due to excretion disorder. In the case of primary liver cancer, the enzyme is synthesized in the liver, which can cause a significant increase in blood transpeptidase, even more than 10 times normal. Alcohol poisoning -GT is also significantly elevated, which is helpful in diagnosing alcoholic liver disease.

Cause

Normal physiology

1. The glutamyl transpeptidase is high due to alcohol abuse, and chronic alcoholism is about 20% to 400% higher.

2, the work pressure, life pressure caused by the human body overload causes, patients of different ages have different degrees of high phenomenon.

Pathological cause

The general medical decisive level is: glutamyl transpeptidase <25U/L, which can exclude pathological and biological variations at the same time, glutamyl transpeptidase is 50-200U/L higher, and should check for organisms including pharmacological causes. Learning variation, glutamyl transpeptidase is high >200U / L, usually hepatobiliary disease.

1. When suffering from acute viral hepatitis, the hepatocyte colony adjacent to the necrotic area is hyperactive, causing an increase in serum glutamyl transpeptidase. This factor is also the most common and the most indispensable.

2. Glutamine transpeptidase is often 1-2 times higher than normal in chronic active hepatitis. If it is elevated for a long time, there may be a tendency of hepatic necrosis.

3, intrahepatic or extrahepatic bile duct obstruction, due to glutamyl transpeptidase excretion blocked, with bile reflux into the blood, there will be high glutamyl transpeptidase.

4. Alcoholic hepatitis and alcoholic cirrhosis patients almost all increase glutamyl transpeptidase, which is an important feature of alcoholic liver disease.

5. In patients with primary or metastatic liver cancer, most of glutamyl transpeptidase is moderately or highly increased, which may be several times or even several times higher than normal, but not all glutamyltranspeptidase increases are The precursor of liver cancer needs to be combined with other examinations to comprehensively judge the condition.

6. In the early stage of primary or secondary biliary cirrhosis, elevated glutamyl transpeptidase may also occur.

7, fatty liver patients also have elevated glutamyl transpeptidase, but in general nutritional fatty liver, serum glutamyl transpeptidase activity is mostly no more than twice the normal value.

an examination

Related inspection

Serum -glutamyltranspeptidase urinary glutamyl transpeptidase (UGGT)

Examination of serum -glutamyl transpeptidase can be performed.

Differential diagnosis

Can be identified with high transpeptidase.

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