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Hypertrophy of knuckles

Introduction
Cause
Examine
Diagnosis

Introduction

Introduction Pachyermoperiostosis is also known as cutaneous hypertrophic periosteal hyperosteogeny and Touraine-Solente-Gole syndrome. The primary may be autosomal dominant. Secondary is also called hyperproliferative osteoarthrosis. Often secondary to a variety of chronic and malignant neoplastic diseases. The pathogenesis is still unclear. Primary: more common in men, often soon after puberty. Secondary: After the middle age, the disease is more common in women, and the skin cannot change. It can be diagnosed based on typical changes in skin and bone.

Cause

Cause

(1) Causes of the disease

The primary may be autosomal dominant. Secondary is also called hyperproliferative osteoarthrosis. Often secondary to a variety of chronic and malignant neoplastic diseases.

(two) pathogenesis

The pathogenesis is still unclear.

Examine

an examination

Related inspection

CT examination of limbs and joints for limb and joint movement

According to the typical changes of skin and bone, it can be diagnosed. X-ray examination shows proliferative periostitis such as tibia, tibia, tibia and ulna, and diffuse periosteal thickening.

Laboratory inspection:

CT examination of bone and joint and soft tissue.

Diagnosis

Differential diagnosis

The disease should be differentiated from acromegaly and thyroid acromegaly.

The disease has two types, primary and secondary.

Primary

More common in men, often onset shortly after puberty. The face, forehead, and head are thick and wrinkled, and the forehead changes particularly prominently. The head is turned back to the cranium, especially the upper eyelids are thick and slack, the ears and lips are also thick, especially large, and the skin of the hands and feet is also thick. The bones of the extremities and the phalanx are hypertrophied, the fingers and toes are sick, and the sacs and knee joints are effusion. The patient has pain in his limbs and his movements are awkward.

2. Secondary

After middle-aged disease, the incidence of women is more common, the skin changes are not significant, the bone lesions are obvious and fast, and the pain is conscious. After the primary disease is alleviated, the bone and skin lesions are alleviated.