Metastases of unknown primary

Introduction Primary metastatic cancer of the metastatic tumor is a type of metastatic malignant tumor confirmed by biopsy but not found in the primary site. It is not easy to find because of small lesions, hidden parts or under the mucosa; and the biological behavior of the tumor is worse, and metastasis occurs earlier. It is especially important to look for the primary lesion carefully in clinical practice. Only when the primary lesion is found and the specimen is treated, the clinical cure rate can be improved. Patients with primary metastatic metastatic cancer account for 0.5% to 0.7% of all cancer patients, as cancer treatment often varies with tissue type.

Cause

The cause of the unexplained metastases in the primary tumor:

A lesion caused by a metastatic malignant tumor that is small, concealed, or located under the mucosa and is not easily found.

an examination

Related inspection

Urine routine fecal occult blood test

Examination and diagnosis of unexplained metastases with primary lesions:

Patients with unexplained metastatic cancer of the primary tumor account for 0.5% to 0.7% of all cancer patients. Because cancer treatment often varies with the type of tissue, it must be fully evaluated. Inquire about the medical history and physical examination in detail, pay special attention to the symptoms and signs of breast and pelvic, prostate, rectal and digestive diseases. Laboratory tests include complete blood count, urine analysis, fecal occult blood test, and serum chemistry (male including acid phosphatase, specific antigen test). X-ray examination is limited to chest X-ray, mammography and abdominal CT. The upper digestive tract series and barium enema are not routine.

Differential diagnosis

Symptoms of confusing metastases of unknown origin:

The obtained cancer tissue should be immunoglobulin immunoperoxidase staining, gene rearrangement examination and electron microscopy, which contribute to the diagnosis of large cell lymphoma.

Peroxidase staining of alpha-fetoprotein or beta-human chorionic gonadotropin contributes to the diagnosis of blastoma.

Tissue examination of estrogen and progesterone receptors helps identify breast cancer.

Prostate-specific antigen immunoperoxidase staining tests are helpful in diagnosing prostate cancer.

Patients with unexplained metastatic cancer of the primary tumor account for 0.5% to 0.7% of all cancer patients. Because cancer treatment often varies with the type of tissue, it must be fully evaluated. Inquire about the medical history and physical examination in detail, pay special attention to the symptoms and signs of breast and pelvic, prostate, rectal and digestive diseases. Laboratory tests include complete blood count, urine analysis, fecal occult blood test, and serum chemistry (male including acid phosphatase, specific antigen test). X-ray examination is limited to chest X-ray, mammography and abdominal CT. The upper digestive tract series and barium enema are not routine.

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