Extraordinarily thick dance-like movements

Introduction Due to the clinical manifestations caused by chronic progressive chorea, dyskinesia initially manifests significant irritability and gradually develops into an abnormally large dance-like movement. Huntington's disease, also known as chronic progressive chorea, is a genetic disease of basal ganglia and cerebral cortical degeneration. It is a rare neurological disease with clinical features of chronic progressive dance-like movements (abnormally large dance-like movements) and dementia. The disease is an autosomal dominant genetic disease. At present, there is no effective treatment. Strengthening premarital examination and pre-pregnancy genetic counseling are important measures to prevent the disease.

Cause

The cause of unusually large dance-like movements:

It is an autosomal dominant genetic disease. The gene is located on autosome 4p16.3 and the gene product is Huntingtin. The pathology is atrophy of the caudate nucleus, followed by the putamen and basal white spheres. Neuronal degeneration and loss, in which gamma-aminobutyric acid (GABA) neurons and cholinergic neurons are significantly lost, dopamine neurons are relatively less lost, and somatostatin neurons are preserved.

an examination

Related inspection

Abdominal wall reflex

Examination and diagnosis of abnormally large dance-like movements:

Diagnosis can be based on clinical symptoms.

1. The disease usually occurs 30 to 40 years old, gradually increased, family history, occasional sporadic cases. In the early stage, mental disorders such as irritability, depression and antisocial behavior can be seen, and advanced progressive dementia; dyskinesia initially manifests obvious irritability and gradually develops into an abnormally large dance-like movement.

2. A few cases of atypical motor symptoms (Westphal variant), showing progressive myotonia and decreased exercise, no dance-like movements, mostly childhood, epilepsy & cerebellar ataxia is also a common feature of adolescents. With dementia and family history.

Differential diagnosis

Symptom identification of abnormally large dance-like movements:

1, senile chorea: occurs in the elderly, can be caused by stroke, acute onset, can present partial dance chorea.

2, dance-like hand and foot Xu movement: paroxysm dance hand and foot hyperkinesis that is involuntary motor syndrome, paroxysmal dance refers to the action, also known as exercise-induced epilepsy, paroxysmal dystonia dance hand and foot hyperactivity disorder , familial paroxysmal ADHD, focal motor-borne paroxysmal dance, hand and foot hyperactivity disorder, secondary paroxysmal ADHD. This symptom is a hereditary, paroxysmal disease that is extremely rare from childhood.

3, dance disease-like movements: chorea is a rapid irregularity of the limbs and head, no rhythm, large and can not recur and control your movements, such as neck, shoulders, finger intermittent extension and extension (milk-like grip), Shaking hands, stretching arms and other dance-like movements, upper limb weight, gait instability or coarse jumping dance-like gait, when heavy, there may be a rapid and large jumping movement from one side to the other (dance-like gait), free movement Or increase your trust when you are emotional, reduce when you are quiet, disappear when you sleep, face muscles can be seen as a ghost face, and your muscles are low. Common in small chorea, Huntington's chorea and application of neuroleptics. Hemiplegia is limited to the body side of the medical insurance, and is common in stroke and brain tumors.

4, dance-like involuntary movement: dance-like involuntary movement is a clinical manifestation of involuntary movement. Involuntary movement or abnormal movement is an involuntary contraction of a part of a muscle, a muscle or a certain muscle group. It refers to the skeletal muscle movement in which the patient has a clear consciousness and cannot control it by himself. Clinically common are fasciculation, muscle fiber twitching, convulsions, convulsions, myoclonus, tremors, dance-like movements, hand and foot movements, and twisting sputum.

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