Diffuse kidney disease

Introduction Diffuse renal disease is a manifestation of kidney damage caused by various kidney diseases. Nephrotic syndrome, referred to as nephropathy, is a group of syndromes with increased glomerular basement membrane permeability. It can be caused by a variety of causes. Its clinical features are massive proteinuria, hypoproteinemia, hypercholesterolemia and systemic edema. . Inflammatory response: mononuclear macrophages, neutrophils, eosinophils, platelets, inflammatory mediators, etc. invade the kidneys. Eventually, the glomerular filtration membrane molecular barrier and the charge barrier are impaired. The permeability of the glomerular filtration membrane to plasma proteins (mainly albumin) increases, and the protein content in the urine increases, when the distal convoluted tubules are exceeded. When the amount of absorption is returned, a large amount of proteinuria is formed.

Cause

It is usually caused by infectious diseases such as urinary tract infections.

an examination

Related inspection

Renal angiography urinary system CT examination

B-ultrasound, urine, blood biochemistry (kidney function serum creatinine) and other comprehensive examination.

Diffuse renal disease is a renal parenchymal damage caused by a variety of causes, the incidence is high, severe renal failure, uremia, leading to death.

Differential diagnosis

Need to distinguish from other kidney diseases such as renal tubular disease

Nephrotic syndrome (NS) is a clinical syndrome in which a large number of albumin is lost from the urine due to the increase of plasma protein permeability in the glomerular filtration membrane, causing a series of pathophysiological changes. The disease is characterized by massive proteinuria, hypoalbuminemia, severe edema, hyperlipidemia, and hypercoagulable state. A large amount of proteinuria refers to a daily discharge of >100 mg/kg of urine protein or more than 3.5 g/L of urine protein. The disease has a tendency to increase year by year.

The material in this site is intended to be of general informational use and is not intended to constitute medical advice, probable diagnosis, or recommended treatments.