Abnormal neuronal migration

Introduction Neuronal migration abnormality refers to the obstruction of neuroblasts from the embryonic germinal matrix to the surface of the brain during various stages of cerebral cortex development, resulting in different degrees of developmental malformation of the brain tissue, including no brain-return Malformations, gray matter ectopic, cerebral schizophrenia, multiple cerebellar malformations, hemi-macrodendritic malformations, and local cortical dysplasia. Each type has specific etiology, pathological changes, and imaging features.

Cause

Including non-cerebral gyrus - giant gyrus, malformation, cerebral schizophrenia, multiple cerebellar malformations, hemi-major malformation and local cortical dysplasia. In general, the most common diagnosis of neuronal migration is cerebral palsy, epilepsy, and mental retardation.

an examination

Related inspection

Brain CT examination of central neurotransmitter and receptor imaging

The clinical symptoms of various neuronal migration abnormalities are most common in epilepsy, and clinical manifestations are generally related to the extent and location of the lesion. Epileptic seizure refers to the clinical phenomenon caused by abnormal brain neurons and excessive hypersynchronous discharge. It is characterized by sudden and transient symptoms, and there are various manifestations of abnormally discharged neurons in the brain. It may be a sensory or autonomic nerve with or without a change in consciousness or alertness.

Differential diagnosis

Neuronal migration abnormalities need to be identified as follows:

Epilepsy: A chronic disease in which sudden abnormal discharge of brain neurons leads to transient brain dysfunction. Epileptic seizure refers to the clinical phenomenon caused by abnormal brain neurons and excessive hypersynchronous discharge. It is characterized by sudden and transient symptoms, and there are various manifestations of abnormally discharged neurons in the brain. It may be a sensory or autonomic nerve with or without a change in consciousness or alertness.

Cerebral palsy: Cerebral palsy is a syndrome characterized by dyskinesia and postural disorder caused by damage or injury within one month before, during or after birth. It is often accompanied by epilepsy. Low intelligence, language barriers, etc. Basically synonymous with pediatric cerebral palsy. Lesions often damage pyramidal and extrapyramidal lines. The disease is directly related to cerebral hypoxia, infection, trauma and hemorrhage, such as rubella, herpes zoster or toxoplasmosis in early pregnancy, severe infection in the middle and late pregnancy, severe pregnancy-induced hypertension syndrome, pathological dystocia, etc. Can cause neonatal cerebral palsy.

Mental retardation (MR): A group of diseases in which the general intellectual function is significantly lower than the same age level and the same amount is accompanied by adaptive behavioral defects. IQ (IQ) is lower than the population mean of 2.0 standard deviation (the IQ of the population is set at 100, the IQ value of a standard deviation is 15), and the general IQ below 70 (or 75) is that the intelligence is significantly lower than the average. Adaptive behavior includes both personal life ability and social responsibility. Developmental period generally refers to under 18 years of age. There are various names for mental retardation. Psychiatry is called "mental retardation", "mental hypoplasia", and "mental defects." Education and psychology are called "intellectual backwardness" and "intellectual defects." Pediatrics is called "intellectual depression," "smart retardation," and "intellectual developmental disorders." Special education schools are called mental disability and intellectual disability.

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