Papules or nodules near the upper lip, in the paranasal groove and on the eyelids

Introduction Multiple hair epithelial tumors are dominant hereditary benign tumor lesions, which are multiple, solid papules or nodules with smooth and slightly transparent surface. The individual lesions are 2 to 4 mm in diameter and are flesh-colored or reddish. , often in groups but isolated, skin lesions occur in the face, especially near the upper lip, paranasal sulcus and eyelids, other parts such as the head, neck and trunk can also occur, skin lesions occur in children or adolescents, more common in women.

Cause

Multiple hair style cases are related to heredity, mostly autosomal dominant inheritance, but single-hair styles have no family history.

an examination

Related inspection

Urine routine blood routine

The multiple hair styles of the disease have certain characteristics in the clinic. They are multiple, symmetrical, normal skin color small nodules or papules, which occur in the face and begin to appear in children or young people. There is a family morbidity, and the rash persists without change, but can A new rash occurs slowly, and the single-hair person has no clinical features and needs to be confirmed by pathological examination.

The disease should be clinically differentiated from Pringle disease (ie, tuberous sclerosis), sweat duct tumor, basal cell nevus syndrome, etc. Clinical identification is sometimes difficult, but tuberous sclerosis often has other complications, for differential diagnosis. Helpful, sweat duct tumors mainly occur around the eyes, and can occur in the neck, chest, back, usually less damage, the size is relatively consistent, basal cell nevus syndrome also occurs in the face, but the disease is not good The hair part can be ruptured early, and often accompanied by bone and central nervous system abnormalities. For pathological examination, the identification is more reliable, pathologically should be related to keratinizing basal cell carcinoma, nodular basal cell carcinoma, Identification of hair adenomas and hair follicle tumors.

Single-type hair epithelial tumors are often mistaken for non-pigmented intradermal fistula. Because there is no special clinical manifestation, pathological examination should be performed, but in pathological examination, differential diagnosis will also encounter difficulties, especially keratinized base. In cell tumors, individual fields of vision are almost indistinguishable and require comprehensive observation before they can be diagnosed. About 30% of the specimens in Gray et al. were initially misdiagnosed as basal cell tumors.

Differential diagnosis

Differential diagnosis of papules or nodules near the upper lip, paranasal sulcus and eyelids:

1, herpes labialis: herpes labialis (face herpes) is the most common type of herpes simplex. The cause is infection with herpes simplex virus. It appears that there are hot, itching and flushing in the beginning, and then there are dense integrated groups or groups of needle-sized blisters, which are smaller and more clustered than the original blister, ruptured and eroded, exudate, and gradually dry. Hey, after about 1 to 2 weeks, the local pigmentation can be left behind. The damage occurs at the junction of the skin and mucous membranes, such as the corners of the mouth, the lips and the nostrils, and also occurs in the face and lips. Herpes labialis (face herpes) is the most common type.

2, the miliary nodules appearing under subcutaneous deposition: oxalate crystal arthritis oxalate crystal deposition in the joint can lead to acute and chronic lesions of a variety of joints, the most commonly involved knee and hand joints, and Other joints, such as wrist, ankle, foot and tendon sheath, and joint capsule lesions have also been reported. Patients treated with hemodialysis or peritoneal dialysis for renal failure can also develop oxalate deposits in the intervertebral disc, which often lead to disruption and degeneration of the intervertebral disc. Deposition of oxalate crystals in other tissues can also lead to the following consequences: local necrosis, myocardial lesions or heart block due to insufficient blood supply, miliary nodules, peripheral neuropathy and aplastic disorders in subcutaneous deposition Anemia.

3, round or oval rash or nodules: round or oval rash or nodules is a symptom of the appearance of cutaneous fibroids.

4, red or purple, slightly elevated pimples or nodules: skin leukemia damage is red or purple slightly higher pimples or nodules; patients with skin myelofibrosis also appear red or purple slightly raised pimples Or nodules. The multiple hair styles of the disease have certain characteristics in the clinic. They are multiple, symmetrical, normal skin color small nodules or papules, which occur in the face and begin to appear in children or young people. There is a family morbidity, and the rash persists without change, but can A new rash occurs slowly, and the single-hair person has no clinical features and needs to be confirmed by pathological examination.

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