Increased deposition of urate in joints

Introduction The deposition of urate in the joints increases, and the repeated episodes of inflammation enter the chronic phase and cannot completely disappear, causing the joint bone erosion defect and the surrounding tissue fibrosis, causing the joint to be stiff and deformed, and the activity is limited. Repeated attacks of acute inflammation make the lesions more and more serious, and the deformity becomes more and more significant, which seriously affects joint function. Individual patients have mild atypical symptoms in the acute phase and are found after the occurrence of joint deformity. A small number of chronic arthritis can affect the large joints and spine of the whole body joints including the shoulder and hip. In addition, urate crystals can be deposited in the tendons, tendon sheaths, and connective tissues of the skin near the joints, forming yellow-white, ridged creatures of different sizes, so-called gout nodules (or tophi), which can be as small as sesame seeds. Eggs or larger, often occur in the ear wheel, forearm extension, metatarsal toe, fingers, elbows, etc., but do not involve the liver, spleen, lungs and central nervous system. At the beginning of the nodule, the texture is soft, and as the fibrous tissue proliferates, the texture becomes harder and harder. The nodules in the vicinity of the joints are easy to wear, and the outer epidermis is thin and easy to break into a fistula. It can be discharged with white powdered urate crystals. However, secondary infection is rare because of bacteriocin. The tissue surrounding the fistula is chronic inflammatory granuloma and is not easy to heal.

Cause

Long-term sputum metabolism disorder, caused by increased blood uric acid. If the blood uric acid concentration is higher than this saturation point for a long time, it is medically called "hyperuricemia." Eating foods that contain too much bismuth, and in the process of metabolism, the body fails to further metabolize sputum into excretion that can be excreted from the kidneys through the urine. If the concentration of uric acid in the blood reaches a saturated solubility, these substances eventually form crystals and accumulate in the soft tissue. If there is a cause to cause the release of uric acid crystals deposited in soft tissues such as the joint membrane or tendon, it will cause allergies in the body's immune system and cause inflammation.

an examination

Related inspection

Uric acid urine routine

Middle-aged men and above, sudden onset of the big toe, sputum, sputum, knee and other single joint swelling and pain, accompanied by increased blood urate, that is, gout may be considered, the sac fluid examination to find urate crystal can establish a diagnosis. General diagnosis is not difficult. Pay attention to the diet, do not eat spicy drinking, check the need to check B-ultrasound, blood, urine, kidney function, liver function. Pay attention to observation.

Differential diagnosis

diabetes

Both diabetes and gout are diseases caused by abnormal metabolism in the body and can easily occur in patients. Diabetes is caused by the lack of insulin hormones regulating blood sugar, which leads to the continuous high blood sugar level in the body; and there is a great correlation between uric acid value and blood sugar level. Generally, those with high uric acid value will have higher blood sugar levels.

High blood pressure/high blood fat

Most patients with gout are relatively obese, and excessive accumulation of fat in the body can easily cause arteriosclerosis and cause high blood pressure. Because the daily diet of gout patients is biased towards high-fat, high-calorie foods, the body's neutral fat content is quite high. Cholesterol values usually exceed normal standards and are one of the most prevalent groups of hyperlipidemia.

[myocardial infarction / angina]

The heart vessels of gout patients are prone to arteriosclerosis, resulting in insufficient blood supply to the heart, poor blood circulation, and a high incidence of angina or myocardial infarction, especially gout that originally suffered from hyperlipidemia. Patients are more prone to heart disease.

Cerebrovascular disorders

The same is caused by the problem of arteriosclerosis, the difference is in the brain. Symptoms include headache, dizziness, numbness or paralysis of the hands and feet. In severe cases, the patient has lost consciousness and even died. In addition to angiography, the patient needs to do CT and MRI examination of the brain. More than a year of men, sudden onset of the big toe, sputum, sputum, knee and other single joint swelling and pain, accompanied by increased blood urate, that is, gout may be considered, the sac fluid examination to find urate crystal can establish a diagnosis. General diagnosis is not difficult.

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